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Your search for gamma secretase returned 14 results

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Ligand: (R)-flurbiprofen
Comments: gamma-secretase modulator (GSM) that blocks gamma-secretase cleavage of amyloid-beta protein precursor (AbetaPP
Bioactivity comments: Mechanism of action thought to be gamma secretase modulation but no quantitiative data reported.
Ligand: begacestat
Comments: gamma-secretase inhibitor (GSI) for Alzheimer's Disease that selectively inhibits cleavage of APP over
Bioactivity comments: gamma-secretase function, and displaces a tritiated analog of GSI-953 from enriched gamma-secretase
Ligand: PF-3084014
Comments: gamma-secretase inhibitor. PF-3084014 also acts as an inhibitor of the NOTCH signalling pathway
Bioactivity comments: gamma-secretase activity with an IC50 of 1.2nM , measured as a reduction of Abeta
Ligand: CHF-5074
Comments: gamma-secretase modulator (GSM). These are small molecules (<600 Da) causing a product shift from
Bioactivity comments: Note as a GSM the potency of gamma secretase inhibition is low
Ligand: RO4929097
Comments: gamma-secretase, was originally developed for Alzheimer's disease but based on its ability to inhibit
Bioactivity comments: RO4929097 strongly inhibits gamma-secretase enzyme activity.
Ligand: semagacestat
Comments: gamma-secretase inhibitor that was developed by Eli Lilly as a potential treatment for Alzheimer
Bioactivity comments: Shows potent Inhibition of gamma secretase-mediated amyloid beta (1 to 40) production in vitro
Family: Notch receptors
(Concise view) family overview: ...gamma-secretase is required for downstream signalling and Notch-induced transcriptional modulation . This is why gamma...
Ligand: ELND006
Bioactivity comments: Gamma secretase inhibition reported as Notch-sparing
Ligand: AZ4800
Comments: gamma secretase modulators . It has recently been used for targeting amyloid beta production in a mouse
Ligand: amyloid β {Sp: Human}
Comments: gamma-secretases. These peptides may be soluble monomers or oligomers and contribute to the formation

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