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Dermatitis

Disease ID:1018
Name:Dermatitis
Associated with:1 target
14 immuno-relevant ligands
Description
Includes atopic, seborrhoeic, and contact dermatitis.
Database Links
Disease Ontology: DOID:2723

Targets

NLRP12

Ligands

Key to terms and symbols Click ligand name to view ligand summary Click column headers to sort
Ligand References Clinical and Disease comments
cortisol
Immuno Disease Comments: Glucocorticoid drug used to treat many inflammatory condtions including dermatitis.
Clinical Use: Hydrocortisone is used to treat many immune and allergic disorders, adrenal insufficiency disorders (eg Addison's disease) and corticosteroid-responsive dermatological disorders (eg psoriasis, atopic dermatitis, and contact dermatitis). | View clinical data
amcinonide
Immuno Disease Comments: A glucocorticoid (corticosteroid) drug used to treat dermatitis.
Clinical Use: Used to treat itching and inflammation associated with allergic and other inflammatory skin conditions. | View clinical data
betamethasone
Immuno Disease Comments: A glucocorticoid (corticosteroid) drug used to treat dermatitis.
Clinical Use: Betamethasone is a synthetic glucocorticoid receptor (GR) agonist, with anti-inflammatory, antipruritic, and vasoconstrictive activities. The drug is used to treat the inflammatory sympotoms of conditions including atopic, seborrhoeic, and contact dermatitis, psoriasis and insect bite reactions. | View clinical data
clobetasol propionate
Immuno Disease Comments: A glucocorticoid (corticosteroid) drug used to treat dermatitis.
Clinical Use: Used to treat skin inflammation and itching caused by conditions such as allergic reactions, eczema, and psoriasis. | View clinical data
desonide
Immuno Disease Comments: A glucocorticoid (corticosteroid) drug used to treat dermatitis.
Clinical Use: Used to reduce skin inflammation caused by allergic reactions, eczema and psoriasis. | View clinical data
Bioactivity Comments: We have been unable to find publicly available affinity data for this drug to substantiate its MMOA, so have not tagged a primary drug target in this case. | View biological activity
desoximetasone
Immuno Disease Comments: A glucocorticoid (corticosteroid) drug used to treat dermatitis.
Clinical Use: Used to reduce skin inflammation caused by allergic reactions, eczema and psoriasis. | View clinical data
diflorasone diacetate
Immuno Disease Comments: A glucocorticoid (corticosteroid) drug used to treat dermatitis.
Clinical Use: Used to reduce skin inflammation caused by allergic reactions, eczema and psoriasis. | View clinical data
fluocinolone acetonide
Immuno Disease Comments: A topically applied corticosteroid used to treat dermatitis.
Clinical Use: Fluocinolone acetonide is the active component in creams used to treat inflammatory and pruritic skin conditions. An intravitreal implant containing fluocinolone acetonide has been approved (US FDA, 2014) for the management of diabetic macular edema. | View clinical data
fluocinonide
Immuno Disease Comments: A topically applied corticosteroid used to treat dermatitis.
Clinical Use: Fluocinonide is the active component in creams used to treat inflammatory and pruritic skin conditions. | View clinical data
fluticasone propionate
Immuno Disease Comments: A topically applied corticosteroid used to treat dermatitis.
Clinical Use: Fluticasone propionate is used for long-term prevention of bronchospasm in asthmatic patients and also is also contained in creams and nasal sprays to control allergy symptoms. In the US, fluticasone propionate is available over-the-counter, as Flonase Allergy Relief®. | View clinical data
diphenylpyraline
Immuno Disease Comments: Antihistamine approved for dermatitis.
Clinical Use: Diphenylpyraline is an antihistamine used to treat allergic rhinitis, hay fever, and allergic skin disorders. There is no information regarding approval for clinical use of this drug on the US FDA website. Other national approval agencies may have granted marketing authorisation. | View clinical data
Bioactivity Comments: We have been unable to find publicly available affinity data for this drug at its proposed molecular target to substantiate its MMOA, and have therefore not tagged a primary drug target. | View biological activity
prednicarbate
Immuno Disease Comments: A glucocorticoid (corticosteroid) drug used to treat dermatitis.
Clinical Use: Prednicarbate is a topical corticosteroid drug [1]. It is used to relieve inflammatory and pruritic symptoms of corticosteroid-responsive skin conditions such as seborrheic or atopic dermatitis, localized neurodermatitis, psoriasis, the late phase of allergic contact dermatitis and the inflammatory phase of xerosis cutis. Prednicarbate is claimed to have low atrophogenic potential compared to other glucocorticoids [2-3]. | View clinical data
Bioactivity Comments: We have been unable to find publicly available affinity data for this drug at its proposed molecular target to substantiate its MMOA, and have therefore not tagged a primary drug target. | View biological activity
clobetasone
Immuno Disease Comments: Approved drug for atopic, irritant or allergic contact and seborrhoeic dermatitis.
Clinical Use: Can be used in adults and children for the relief of the inflammatory and pruritic manifestations of steroid responsive dermatoses such as:
- atopic dermatitis
- irritant or allergic contact dermatitis
- seborrhoeic dermatitis
- nappy rash
- photodermatitis
- otitis externa
- prurigo nodularis
- insect bite reactions | View clinical data
compound 8ic [PMID: 19081254]
Immuno Disease Comments: Compound has anti-inflammatory activity in a murine model of acute dermatitis.
Bioactivity Comments: CCR4 antagonist activities of the synthesized compounds were determined by measuring the degree to which human CCL22-derived [35S]GTPγS was prevented from binding to the receptor. | View biological activity

References

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1. Gupta AK, Chow M. (2004) A review of prednicarbate (Dermatop). Skin Therapy Lett., 9 (10): 5-6, 9. [PMID:15657633]

2. Kerscher MJ, Korting HC. (1992) Topical glucocorticoids of the non-fluorinated double-ester type. Lack of atrophogenicity in normal skin as assessed by high-frequency ultrasound. Acta Derm. Venereol., 72 (3): 214-6. [PMID:1357864]

3. Korting HC, Vieluf D, Kerscher M. (1992) 0.25% prednicarbate cream and the corresponding vehicle induce less skin atrophy than 0.1% betamethasone-17-valerate cream and 0.05% clobetasol-17-propionate cream. Eur. J. Clin. Pharmacol., 42 (2): 159-61. [PMID:1618247]