Alcoholic liver disease

Disease ID:1159
Name:Alcoholic liver disease
Associated with:1 targets
0 immuno-relevant targets
0 immuno-relevant ligands
Synonyms
alcoholic hepatosteatosis
Description
Alcoholic liver disease encompasses the hepatic pathologies attributable to alcohol overconsumption. Such manifestations include fatty liver, alcoholic hepatitis, and chronic hepatitis with liver fibrosis or cirrhosis.

Targets

regulator of G-protein signaling 6
Role:  In addition to its G protein modulatory function, RGS6 is reported to promote reactive oxygen species-dependent apoptosis which is associated with alcohol-mediated toxicity in the heart, liver, and gastrointestinal tract.
References:  1

Ligands

No ligand related data available for Alcoholic liver disease

References

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1. Stewart A, Maity B, Anderegg SP, Allamargot C, Yang J, Fisher RA. (2015) Regulator of G protein signaling 6 is a critical mediator of both reward-related behavioral and pathological responses to alcohol. Proc. Natl. Acad. Sci. U.S.A., 112 (7): E786-95. [PMID:25646431]