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Atrial Fibrillation

Disease ID:1180
Name:Atrial Fibrillation
Associated with:2 targets

Targets

KCa2.2
Drugs:  NS8593 and UCL1684 have demonstrated efficacy in protecting against or terminating atrial fibrillation both ex vivo and in vivo in rats, dogs, pigs and horses.
Side effects:  Tremor, ataxia and convulsions at higher NS8593 doses.
Therapeutic use:  Negative KCa2 channel gating modulators have been proposed for the treatment of atrial fibrillation.
References:  2,4,7
KCa2.3
Comments:  Common variants in KCNN3 are associated with lone atrial fibrillation.
Significant association of SNP rs2106261 in the ZFHX3 gene with atrial fibrillation in a Chinese Han GeneID population.
Significant association of rs13376333 in KCNN3 on chromosome 1q21 with atrial fibrillation in a Taiwanese population.
Regulation of the SK3 channel by microRNA-499--potential role in atrial fibrillation.
Next-generation sequencing of nine atrial fibrillation candidate genes identified novel de novo mutations in patients with extreme trait of atrial fibrillation
KCNN3 SNP rs13376333 on Chromosome 1q21 Confers Increased Risk of Atrial Fibrillation.
References:  1,3,5-6,8-9

Ligands

No ligand related data available for Atrial Fibrillation

References

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1. Chang SH, Chang SN, Hwang JJ, Chiang FT, Tseng CD, Lee JK, Lai LP, Lin JL, Wu CK, Tsai CT. (2012) Significant association of rs13376333 in KCNN3 on chromosome 1q21 with atrial fibrillation in a Taiwanese population. Circ. J., 76 (1): 184-8. [PMID:22019810]

2. Diness JG, Skibsbye L, Jespersen T, Bartels ED, Sørensen US, Hansen RS, Grunnet M. (2011) Effects on atrial fibrillation in aged hypertensive rats by Ca(2+)-activated K(+) channel inhibition. Hypertension, 57 (6): 1129-35. [PMID:21502564]

3. Ellinor PT, Lunetta KL, Glazer NL, Pfeufer A, Alonso A, Chung MK, Sinner MF, de Bakker PI, Mueller M, Lubitz SA et al.. (2010) Common variants in KCNN3 are associated with lone atrial fibrillation. Nat. Genet., 42 (3): 240-4. [PMID:20173747]

4. Haugaard MM, Hesselkilde EZ, Pehrson S, Carstensen H, Flethøj M, Præstegaard KF, Sørensen US, Diness JG, Grunnet M, Buhl R et al.. (2015) Pharmacologic inhibition of small-conductance calcium-activated potassium (SK) channels by NS8593 reveals atrial antiarrhythmic potential in horses. Heart Rhythm, 12 (4): 825-35. [PMID:25542425]

5. Li C, Wang F, Yang Y, Fu F, Xu C, Shi L, Li S, Xia Y, Wu G, Cheng X et al.. (2011) Significant association of SNP rs2106261 in the ZFHX3 gene with atrial fibrillation in a Chinese Han GeneID population. Hum. Genet., 129 (3): 239-46. [PMID:21107608]

6. Ling TY, Wang XL, Chai Q, Lau TW, Koestler CM, Park SJ, Daly RC, Greason KL, Jen J, Wu LQ et al.. (2013) Regulation of the SK3 channel by microRNA-499--potential role in atrial fibrillation. Heart Rhythm, 10 (7): 1001-9. [PMID:23499625]

7. Qi XY, Diness JG, Brundel BJ, Zhou XB, Naud P, Wu CT, Huang H, Harada M, Aflaki M, Dobrev D et al.. (2014) Role of small-conductance calcium-activated potassium channels in atrial electrophysiology and fibrillation in the dog. Circulation, 129 (4): 430-40. [PMID:24190961]

8. Tsai CT, Hsieh CS, Chang SN, Chuang EY, Juang JM, Lin LY, Lai LP, Hwang JJ, Chiang FT, Lin JL. (2015) Next-generation sequencing of nine atrial fibrillation candidate genes identified novel de novo mutations in patients with extreme trait of atrial fibrillation. J. Med. Genet., 52 (1): 28-36. [PMID:25391453]

9. Yao JL, Zhou YF, Yang XJ, Qian XD, Jiang WP. (2015) KCNN3 SNP rs13376333 on Chromosome 1q21 Confers Increased Risk of Atrial Fibrillation. Int Heart J, 56 (5): 511-5. [PMID:26370375]