Allergic rhinitis

Disease ID:1190
Name:Allergic rhinitis
Associated with:0 targets
0 immuno-relevant targets
13 immuno-relevant ligands
Synonyms
atopic rhinitis | hay fever | Non-seasonal allergic rhinitis | Perenial allergic rhinitis | pollenosis | seasonal allergic rhinitis
Description
A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites.(DOID)
Database Links
Disease Ontology: DOID:4481

Targets

No target related data available for Allergic rhinitis

Ligands

Ligand Approved Immuno References Clinical comments
GSK2245035 1
Clinical Use: GSK2245035 has completed Phase 2 clinical trials in patients with asthma and allergic rhinitis. Results from early clinical evaluation in trials for allergic rhinitis, NCT01480271 (Phase 1) and NCT01607372 (Phase 2), are reported in [3], and results from NCT02446613 reported in [1].
Immuno Disease Comments: Phase 2 clinical candidate for allergic rhinitis- administered intranasally.
desloratadine  [  (Drugs.com) ]
Clinical Use: Desloratadine is used to treat the symptoms (eg rhinitis and urticaria) of many allergic conditions. In some countries this drug is available without prescription.
Immuno Disease Comments: Antihistamine approved for many allergic conditions.
fexofenadine  [  (Drugs.com) ]
Clinical Use: Fexofenadine is used to treat the symptoms of seasonal allergies and other histamine-dependent conditions.
Immuno Disease Comments: Antihistamine approved for the treatment of the symptoms of seasonal allergies.
clemastine  [  (Drugs.com) ]
Clinical Use: Used to treat hay fever, rhinitis, allergic skin conditions, and pruritus
Immuno Disease Comments: A sedating antihistamine used to treat the symptoms of allergic rhinitis.
fluticasone propionate  [  (Drugs.com) ]
Clinical Use: Fluticasone propionate is used for long-term prevention of bronchospasm in asthmatic patients and also is also contained in creams and nasal sprays to control allergy symptoms. In the US, fluticasone propionate is available over-the-counter, as Flonase Allergy Relief®.
Immuno Disease Comments: A glucocorticoid (corticosteroid) drug that can be used to manage the symptoms of allergic rhinitis.
azatadine  [  (Drugs.com) ]
Clinical Use: Used to reduce symptoms of allergies (such as sneezing, itching, runny nose and watery eyes, rashes).
Immuno Disease Comments: Approved drug for allergic rhinitis.
diphenylpyraline  [  (Drugs.com) ]
Clinical Use: Diphenylpyraline is an antihistamine used to treat allergic rhinitis, hay fever, and allergic skin disorders. There is no information regarding approval for clinical use of this drug on the US FDA website. Other national approval agencies may have granted marketing authorisation.
Immuno Disease Comments: Approved antihistamine for allergic rhinitis, hay fever, and allergic skin disorders.
loratadine  [  (Drugs.com) ]
Clinical Use: Loratidine is used to relieve the symptoms of allergic rhinitis and chronic idiopathic urticaria.
Immuno Disease Comments: Antihistamine approved for allergic rhinitis.
tripelennamine  [  (Drugs.com) ]
Clinical Use: Used as an antipruritic and antihistamine in the treatment of asthma, hay fever, rhinitus and urticaria. All formulations of this drug appear to have been discontinued by the US FDA, although other national approval agencies may continue to grant marketing authorisation.
Immuno Disease Comments: Antihistamine approved for allergic rhinitis.
dectrekumab
Clinical Use: Dectrekumab (QBX258) reached Phase II clinical trial as a potential biologic therapy for several immune conditions, including idiopathic pulmonary fibrosis (IPF), asthma, eosinophilic esophagitis [2] (proof of principle study NCT01022970), Crohn's disease, keloids and allergic rhinitis. As of May 2017, there are no active dectrekumab studies.
Immuno Disease Comments: Phase 2 trial NCT00584584 in allergic rhinitis has been completed.
QAV680
Clinical Use: QAV680 reached Phase II clinical trial in asthma and allergic rhinitis. As of May 2017, there are no active clinical trials evaluating this compound.
Immuno Disease Comments: Completed Phase 2 trial in allergic rhinitis (see NCT01103050).
mometasone  [  (Drugs.com) ]
Clinical Use: Mometasone is used intranasally in the management of asthma, allergic rhinitis and nasal polyposis, and topically for allergic skin disorders. Prescribed formulations contain mometasone furoate (PubChem CID 441336).
Immuno Disease Comments: A corticosteroid drug used in the management of allergic rhinitis and nasal polyposis.
timapiprant
Clinical Use: OC000459 is being evaluated in several Phase 2 clinical trials in various inflammatory and allergic conditions including asthma, allergic rhinitis and atopic dermatitis. Click here to link to a list of Phase 2 OC000459 trials registered with ClinicalTrials.gov.
Immuno Disease Comments: Phase 2 clinical candidate for allergic rhinitis.

References

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1. Ellis AK, Tsitoura DC, Quint D, Powley W, Lee LA. (2017) Safety and pharmacodynamics of intranasal GSK2245035, a TLR7 agonist for allergic rhinitis: A randomized trial. Clin. Exp. Allergy, 47 (9): 1193-1203. [PMID:28681506]

2. Rothenberg ME, Wen T, Greenberg A, Alpan O, Enav B, Hirano I, Nadeau K, Kaiser S, Peters T, Perez A et al.. (2015) Intravenous anti-IL-13 mAb QAX576 for the treatment of eosinophilic esophagitis. J. Allergy Clin. Immunol., 135 (2): 500-7. [PMID:25226850]

3. Tsitoura D, Ambery C, Price M, Powley W, Garthside S, Biggadike K, Quint D. (2015) Early clinical evaluation of the intranasal TLR7 agonist GSK2245035: Use of translational biomarkers to guide dosing and confirm target engagement. Clin. Pharmacol. Ther., 98 (4): 369-80. [PMID:26044169]