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Cancer

Disease ID:174
Name:Cancer
Associated with:2 targets
Database Links
Disease Ontology: DOID:162

Targets

FZD5
References:  3
regulator of G-protein signaling 18
Role:  RGS18 is induced in solid tumors of the kidney and stomach and is down regulated in solid tumors of the colon and lung. RGS18 is also induced in diffuse large B, unspecified peripheral T-cell and follicular lymphomas and is down regulated in acute lymphoblastic leukemina (B-cell) and chronic lymphocytic leukemia.
References:  1-2

Ligands

No ligand related data available for Cancer

References

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1. Hurst JH, Hooks SB. (2009) Regulator of G-protein signaling (RGS) proteins in cancer biology. Biochem. Pharmacol., 78 (10): 1289-97. [PMID:19559677]

2. Sethakorn N, Dulin NO. (2013) RGS expression in cancer: oncomining the cancer microarray data. J. Recept. Signal Transduct. Res., 33 (3): 166-71. [PMID:23464602]

3. Ueno K, Hirata H, Hinoda Y, Dahiya R. (2013) Frizzled homolog proteins, microRNAs and Wnt signaling in cancer. Int. J. Cancer, 132 (8): 1731-40. [PMID:22833265]