Abdominal obesity-metabolic syndrome 1; AOMS1

Disease ID:18
Name:Abdominal obesity-metabolic syndrome 1; AOMS1
Associated with:2 targets
0 immuno-relevant targets
0 immuno-relevant ligands
Synonyms
Metabolic syndrome X
Database Links
Disease Ontology: DOID:14221
OMIM: 605552

Targets

Peroxisome proliferator-activated receptor-γ
Comments:  Dominant negative PPAR-gamma mutations in humans result in features associated with metabolic syndrome (severe insulin resistance, dyslipidemia and hypertension).
References:  1-3
Estrogen receptor-α
Role:  Insulin resistence and diabetes present
References:  4

Ligands

No ligand related data available for Abdominal obesity-metabolic syndrome 1; AOMS1

References

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1. Desvergne B, Michalik L, Wahli W. (2004) Be fit or be sick: peroxisome proliferator-activated receptors are down the road. Mol. Endocrinol., 18 (6): 1321-32. [PMID:15087471]

2. Freedman BD, Lee EJ, Park Y, Jameson JL. (2005) A dominant negative peroxisome proliferator-activated receptor-gamma knock-in mouse exhibits features of the metabolic syndrome. J. Biol. Chem., 280 (17): 17118-25. [PMID:15716267]

3. Lee CH, Olson P, Evans RM. (2003) Minireview: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors. Endocrinology, 144 (6): 2201-7. [PMID:12746275]

4. Simpson E, Jones M, Misso M, Hewitt K, Hill R, Maffei L, Carani C, Boon WC. (2005) Estrogen, a fundamental player in energy homeostasis. J. Steroid Biochem. Mol. Biol., 95 (1-5): 3-8. [PMID:16054355]