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Colorectal cancer

Disease ID:233
Name:Colorectal cancer
Associated with:18 targets
Database Links
Disease Ontology: DOID:9256
OMIM: 114500

Targets

CXCR5
References:  5,9
FZD7
References:  4,12
PKR1
References:  7
Mutations:  PKR1 is associated with 8 mutation. Click here for details
Peroxisome proliferator-activated receptor-γ
Comments:  Human colon cancer is associated with loss-of function mutations in PPAR-gamma ligand-binding domain, potential antitumor efficacity of combining RXR and PPAR-gamma agonist
References:  1,3,10-11
Ornithine decarboxylase
Role:  A polymorphism in ODC1 is associated with reduced risk of colonic adenoma recurrence.
References:  14
sPLA2-2A
AKT serine/threonine kinase 1
TLR2
TLR3
TLR4
NLRP6
aurora kinase A
B-Raf proto-oncogene, serine/threonine kinase
Mutations:  B-Raf proto-oncogene, serine/threonine kinase is associated with 1 mutation. Click here for details
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
E1A binding protein p300
regulator of G-protein signaling 16
References:  6
regulator of G-protein signaling 12
Comments:  Colorectal tumors with high microsatellite instability
References:  8,13
NRAS

Ligands

No ligand related data available for Colorectal cancer

References

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1. Cesario RM, Stone J, Yen WC, Bissonnette RP, Lamph WW. (2006) Differentiation and growth inhibition mediated via the RXR:PPARgamma heterodimer in colon cancer. Cancer Lett., 240 (2): 225-33. [PMID:16271436]

2. Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, Teague J, Woffendin H, Garnett MJ, Bottomley W et al.. (2002) Mutations of the BRAF gene in human cancer. Nature, 417 (6892): 949-54. [PMID:12068308]

3. Kim E, Chen F, Wang CC, Harrison LE. (2006) CDK5 is a novel regulatory protein in PPARgamma ligand-induced antiproliferation. Int. J. Oncol., 28 (1): 191-4. [PMID:16327995]

4. King TD, Zhang W, Suto MJ, Li Y. (2012) Frizzled7 as an emerging target for cancer therapy. Cell. Signal., 24 (4): 846-51. [PMID:22182510]

5. Meijer J, Zeelenberg IS, Sipos B, Roos E. (2006) The CXCR5 chemokine receptor is expressed by carcinoma cells and promotes growth of colon carcinoma in the liver. Cancer Res., 66 (19): 9576-82. [PMID:17018614]

6. Miyoshi N, Ishii H, Sekimoto M, Doki Y, Mori M. (2009) RGS16 is a marker for prognosis in colorectal cancer. Ann. Surg. Oncol., 16 (12): 3507-14. [PMID:19760045]

7. O'Hayre M, Vázquez-Prado J, Kufareva I, Stawiski EW, Handel TM, Seshagiri S, Gutkind JS. (2013) The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer. Nat. Rev. Cancer, 13 (6): 412-24. [PMID:23640210]

8. Potocnik U, Glavac D, Ravnik-Glavac M. (2003) Identification of novel genes with somatic frameshift mutations within coding mononucleotide repeats in colorectal tumors with high microsatellite instability. Genes Chromosomes Cancer, 36 (1): 48-56. [PMID:12461749]

9. Qi XW, Xia SH, Yin Y, Jin LF, Pu Y, Hua D, Wu HR. (2014) Expression features of CXCR5 and its ligand, CXCL13 associated with poor prognosis of advanced colorectal cancer. Eur Rev Med Pharmacol Sci, 18 (13): 1916-24. [PMID:25010623]

10. Sarraf P, Mueller E, Smith WM, Wright HM, Kum JB, Aaltonen LA, de la Chapelle A, Spiegelman BM, Eng C. (1999) Loss-of-function mutations in PPAR gamma associated with human colon cancer. Mol. Cell, 3 (6): 799-804. [PMID:10394368]

11. Sasaki T, Fujii K, Yoshida K, Shimura H, Sasahira T, Ohmori H, Kuniyasu H. (2006) Peritoneal metastasis inhibition by linoleic acid with activation of PPARgamma in human gastrointestinal cancer cells. Virchows Arch., 448 (4): 422-7. [PMID:16362414]

12. Ueno K, Hiura M, Suehiro Y, Hazama S, Hirata H, Oka M, Imai K, Dahiya R, Hinoda Y. (2008) Frizzled-7 as a potential therapeutic target in colorectal cancer. Neoplasia, 10 (7): 697-705. [PMID:18592008]

13. Williams DS, Bird MJ, Jorissen RN, Yu YL, Walker F, Walker F, Zhang HH, Nice EC, Burgess AW. (2010) Nonsense mediated decay resistant mutations are a source of expressed mutant proteins in colon cancer cell lines with microsatellite instability. PLoS ONE, 5 (12): e16012. [PMID:21209843]

14. Zell JA, Ziogas A, Ignatenko N, Honda J, Qu N, Bobbs AS, Neuhausen SL, Gerner EW, Anton-Culver H. (2009) Associations of a polymorphism in the ornithine decarboxylase gene with colorectal cancer survival. Clin. Cancer Res., 15 (19): 6208-16. [PMID:19789310]