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Emesis

Disease ID:295
Name:Emesis
Associated with:2 targets

Targets

5-HT3B
Comments:  This deletion variant in the promotor region of the HTR3B gene increases promoter activity in vitro and has been associated with an increased incidence of paroxetine-induced nausea, and with an increased frequency of vomiting caused by chemotherapy in patients receiving 5-HT3 receptor antagonists as anti-emetic therapy.
References:  2-4
Mutations:  5-HT3B is associated with 1 mutation. Click here for details
5-HT3C
Comments:  This polymorphism is associated with an increased frequency of vomiting in patients receiving anthracycline chemotherapy.
References:  1
Mutations:  5-HT3C is associated with 1 mutation. Click here for details

Ligands

No ligand related data available for Emesis

References

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1. Fasching PA, Kollmannsberger B, Strissel PL, Niesler B, Engel J, Kreis H, Lux MP, Weihbrecht S, Lausen B, Bani MR, Beckmann MW, Strick R. (2008) Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy. J. Cancer Res. Clin. Oncol., 134 (10): 1079-86. [PMID:18389280]

2. Meineke C, Tzvetkov MV, Bokelmann K, Oetjen E, Hirsch-Ernst K, Kaiser R, Brockmöller J. (2008) Functional characterization of a -100_-102delAAG deletion-insertion polymorphism in the promoter region of the HTR3B gene. Pharmacogenet. Genomics, 18 (3): 219-30. [PMID:18300944]

3. Tanaka M, Kobayashi D, Murakami Y, Ozaki N, Suzuki T, Iwata N, Haraguchi K, Ieiri I, Kinukawa N, Hosoi M, Ohtani H, Sawada Y, Mine K. (2008) Genetic polymorphisms in the 5-hydroxytryptamine type 3B receptor gene and paroxetine-induced nausea. Int. J. Neuropsychopharmacol., 11 (2): 261-7. [PMID:17697394]

4. Tremblay PB, Kaiser R, Sezer O, Rosler N, Schelenz C, Possinger K, Roots I, Brockmoller J. (2003) Variations in the 5-hydroxytryptamine type 3B receptor gene as predictors of the efficacy of antiemetic treatment in cancer patients. J. Clin. Oncol., 21 (11): 2147-55. [PMID:12775740]