Alcohol dependence

Disease ID:48
Name:Alcohol dependence
Associated with:6 targets
0 immuno-relevant targets
0 immuno-relevant ligands
Database Links
Disease Ontology: DOID:0050741
OMIM: 103780

Targets

KCa2.2
Drugs:  EBIO and chlorzoxazone reduce excessive alcohol intake in rats; EBIO alleviates withdrawal hyperexcitability and attenuates ethanol withdrawal neurotoxicity in hippocampus in mice.
Side effects:  Sedation and impairment of motor coordination at higher doses.
Therapeutic use:  KCa2 activators have been suggested for the treatment of alcohol dependence and other addictions
References:  3-6
GABAA receptor α2 subunit
Comments:  Polymorphisms in GABRA2 are associated with susceptibility to alcohol dependence
References:  1-2

Ligands

No ligand related data available for Alcohol dependence

References

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1. Arias AJ, Covault J, Feinn R, Pond T, Yang BZ, Ge W, Oncken C, Kranzler HR. (2014) A GABRA2 variant is associated with increased stimulation and 'high' following alcohol administration. Alcohol Alcohol., 49 (1): 1-9. [PMID:24166645]

2. Bierut LJ, Agrawal A, Bucholz KK, Doheny KF, Laurie C, Pugh E, Fisher S, Fox L, Howells W, Bertelsen S et al.. (2010) A genome-wide association study of alcohol dependence. Proc. Natl. Acad. Sci. U.S.A., 107 (11): 5082-7. [PMID:20202923]

3. Hopf FW, Bowers MS, Chang SJ, Chen BT, Martin M, Seif T, Cho SL, Tye K, Bonci A. (2010) Reduced nucleus accumbens SK channel activity enhances alcohol seeking during abstinence. Neuron, 65 (5): 682-94. [PMID:20223203]

4. Hopf FW, Seif T, Bonci A. (2011) The SK channel as a novel target for treating alcohol use disorders. Channels (Austin), 5 (4): 289-92. [PMID:21712648]

5. Hopf FW, Simms JA, Chang SJ, Seif T, Bartlett SE, Bonci A. (2011) Chlorzoxazone, an SK-type potassium channel activator used in humans, reduces excessive alcohol intake in rats. Biol. Psychiatry, 69 (7): 618-24. [PMID:21195386]

6. Mulholland PJ, Becker HC, Woodward JJ, Chandler LJ. (2011) Small conductance calcium-activated potassium type 2 channels regulate alcohol-associated plasticity of glutamatergic synapses. Biol. Psychiatry, 69 (7): 625-32. [PMID:21056409]