Antiphospholipid syndrome

Disease ID:73
Name:Antiphospholipid syndrome
Associated with:1 targets
0 immuno-relevant targets
0 immuno-relevant ligands
Database Links
Disease Ontology: DOID:2988
OMIM: 107320
Orphanet: ORPHA80

Targets

C5a1 receptor
Role:  C5aR functions as the activating receptor for neutrophils in antiphospholipid syndrome, neutrophil activation leads to the oxidative damage and pregancy loss characteristic of aPLS. Mice deficient in C5, or pharmacological blockage of C5aR, exhibit increased foetal growth and decreased foetal loss in aPLS.
References:  1-2

Ligands

No ligand related data available for Antiphospholipid syndrome

References

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1. Girardi G, Berman J, Redecha P, Spruce L, Thurman JM, Kraus D, Hollmann TJ, Casali P, Caroll MC, Wetsel RA et al.. (2003) Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome. J. Clin. Invest., 112 (11): 1644-54. [PMID:14660741]

2. Weiler H. (2008) Tracing the molecular pathogenesis of antiphospholipid syndrome. J. Clin. Invest., 118 (10): 3276-8. [PMID:18802489]