Lanosterol biosynthesis pathway C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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Lanosterol is a precursor for cholesterol, which is synthesized primarily in the liver in a pathway often described as the mevalonate or HMG-CoA reductase pathway. The first two steps (formation of acetoacetyl CoA and the mitochondrial generation of (S)-3-hydroxy-3-methylglutaryl-CoA) are also associated with oxidation of fatty acids.

Enzymes

acetyl-CoA acetyltransferase 1 C Show summary » More detailed page

acetyl-CoA acetyltransferase 2 C Show summary » More detailed page

hydroxymethylglutaryl-CoA synthase 1 C Show summary » More detailed page

hydroxymethylglutaryl-CoA synthase 2 C Show summary » More detailed page

hydroxymethylglutaryl-CoA reductase C Show summary » More detailed page

mevalonate kinase C Show summary » More detailed page

phosphomevalonate kinase C Show summary » More detailed page

diphosphomevalonate decarboxylase C Show summary » More detailed page

isopentenyl-diphosphate Δ-isomerase 1 C Show summary » More detailed page

isopentenyl-diphosphate Δ-isomerase 2 C Show summary » More detailed page

geranylgeranyl diphosphate synthase C Show summary » More detailed page

farnesyl diphosphate synthase C Show summary » More detailed page

squalene synthase C Show summary » More detailed page

squalene monooxygenase C Show summary » More detailed page

lanosterol synthase C Show summary » More detailed page

Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Helen E. Benson. Lanosterol biosynthesis pathway. Accessed on 23/09/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=104.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Enzymes. Br J Pharmacol. 172: 6024-6109.