Taste 2 receptors

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Whilst the taste of acid and salty foods appear to be sensed by regulation of ion channel activity, bitter, sweet and umami tastes are sensed by specialised GPCR. Two classes of taste GPCR have been identified, T1R and T2R, which are similar in sequence and structure to Class C and Class A GPCR, respectively. Activation of taste receptors appears to involve gustducin- (Gαt3) and Gα14-mediated signalling, although the precise mechanisms remain obscure. Gene disruption studies suggest the involvement of PLCβ2 [7], TRPM5 [7] and IP3 [3] receptors in post-receptor signalling of taste receptors. Although predominantly associated with the oral cavity, taste receptors are also located elsewhere, including further down the gastrointestinal system, in the lungs and in the brain.

Bitter
The composition and stoichiometry of bitter taste receptors is not yet established. Bitter receptors appear to separate into two groups, with very restricted ligand specificity or much broader responsiveness. For example, T2R5 responded to cycloheximide, but not 10 other bitter compounds [2], while T2R14 responded to at least eight different bitter tastants, including (-)-α-thujone and picrotoxinin [1].

Specialist database BitterDB contains additional information on bitter compounds and receptors [6].

Receptors

TAS2R1 Show summary »

TAS2R3 Show summary »

TAS2R4 Show summary »

TAS2R5 Show summary »

TAS2R7 Show summary »

TAS2R8 Show summary »

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TAS2R10 Show summary »

TAS2R13 Show summary »

TAS2R14 Show summary »

TAS2R16 Show summary »

TAS2R19 Show summary »

TAS2R20 Show summary »

TAS2R30 Show summary »

TAS2R31 Show summary »

TAS2R38 Show summary »

TAS2R39 Show summary »

TAS2R40 Show summary »

TAS2R41 Show summary »

TAS2R42 Show summary »

TAS2R43 Show summary »

TAS2R45 Show summary »

TAS2R46 Show summary »

TAS2R50 Show summary »

TAS2R60 Show summary »

References

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How to cite this family page

Database page citation:

Taste 2 receptors. Accessed on 23/03/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=117.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Davenport AP, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors. Br J Pharmacol. 172: 5744-5869.