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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Maxi Cl- channels are high conductance, anion selective, channels initially characterised in skeletal muscle and subsequently found in many cell types including neurones, glia, cardiac muscle, lymphocytes, secreting and absorbing epithelia, macula densa cells of the kidney and human placenta syncytiotrophoblasts . The physiological significance of the maxi Cl- channel is uncertain, but roles in cell volume regulation and apoptosis have been claimed. Evidence suggests a role for maxi Cl- channels as a conductive pathway in the swelling-induced release of ATP from mouse mammary C127i cells that may be important for autocrine and paracrine signalling by purines [4,8]. A similar channel mediates ATP release from macula densa cells within the thick ascending of the loop of Henle in response to changes in luminal NaCl concentration . A family of human high conductance Cl- channels (TTYH1-3) that resemble Maxi Cl- channels has been cloned , but alternatively, Maxi Cl- channels have also been suggested to correspond to the voltage-dependent anion channel, VDAC, expressed at the plasma membrane [1,5].
1. Bahamonde MI, Fernández-Fernández JM, Guix FX, Vázquez E, Valverde MA. (2003) Plasma membrane voltage-dependent anion channel mediates antiestrogen-activated maxi Cl- currents in C1300 neuroblastoma cells. J. Biol. Chem., 278 (35): 33284-9. [PMID:12794078]
2. Bell PD, Lapointe JY, Sabirov R, Hayashi S, Peti-Peterdi J, Manabe K, Kovacs G, Okada Y. (2003) Macula densa cell signaling involves ATP release through a maxi anion channel. Proc. Natl. Acad. Sci. U.S.A., 100 (7): 4322-7. [PMID:12655045]
3. Diaz M, Bahamonde MI, Lock H, Muñoz FJ, Hardy SP, Posas F, Valverde MA. (2001) Okadaic acid-sensitive activation of Maxi Cl(-) channels by triphenylethylene antioestrogens in C1300 mouse neuroblastoma cells. J. Physiol. (Lond.), 536 (Pt 1): 79-88. [PMID:11579158]
4. Dutta AK, Okada Y, Sabirov RZ. (2002) Regulation of an ATP-conductive large-conductance anion channel and swelling-induced ATP release by arachidonic acid. J. Physiol. (Lond.), 542 (Pt 3): 803-16. [PMID:12154180]
5. Okada SF, O'Neal WK, Huang P, Nicholas RA, Ostrowski LE, Craigen WJ, Lazarowski ER, Boucher RC. (2004) Voltage-dependent anion channel-1 (VDAC-1) contributes to ATP release and cell volume regulation in murine cells. J. Gen. Physiol., 124 (5): 513-26. [PMID:15477379]
6. Osteen JD, Mindell JA. (2008) Insights into the ClC-4 transport mechanism from studies of Zn2+ inhibition. Biophys. J., 95 (10): 4668-75. [PMID:18658230]
7. Riquelme G. (2009) Placental chloride channels: a review. Placenta, 30 (8): 659-69. [PMID:19604577]
8. Sabirov RZ, Dutta AK, Okada Y. (2001) Volume-dependent ATP-conductive large-conductance anion channel as a pathway for swelling-induced ATP release. J. Gen. Physiol., 118 (3): 251-66. [PMID:11524456]
9. Sabirov RZ, Okada Y. (2009) The maxi-anion channel: a classical channel playing novel roles through an unidentified molecular entity. J Physiol Sci, 59 (1): 3-21. [PMID:19340557]
10. Schulz P, Werner J, Stauber T, Henriksen K, Fendler K. (2010) The G215R mutation in the Cl-/H+-antiporter ClC-7 found in ADO II osteopetrosis does not abolish function but causes a severe trafficking defect. PLoS ONE, 5 (9): e12585. [PMID:20830208]
11. Suzuki M, Mizuno A. (2004) A novel human Cl(-) channel family related to Drosophila flightless locus. J. Biol. Chem., 279 (21): 22461-8. [PMID:15010458]
Database page citation:
Maxi chloride channel. Accessed on 23/04/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=131.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Other ion channels. Br J Pharmacol. 172: 5942-5955.