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Together with the SLC26 family, the SLC4 family of transporters subserve anion exchange, principally of chloride and bicarbonate (HCO3-), but also carbonate and hydrogen sulphate (HSO4-). SLC4 family members regulate bicarbonate fluxes as part of carbon dioxide movement, chyme neutralization and reabsorption in the kidney.
Within the family, subgroups of transporters are identifiable: the electroneutral sodium-independent Cl-/HCO3- transporters (AE1, AE2 and AE3), the electrogenic sodium-dependent HCO3- transporters (NBCe1 and NBCe2) and the electroneutral HCO3- transporters (NBCn1 and NBCn2). Topographical information derives mainly from study of AE1, abundant in erythrocytes, which suggests a dimeric or tetrameric arrangement, with subunits made up of 13 TM domains and re-entrant loops at TM9/10 and TM11/12. The N terminus exhibits sites for interaction with multiple proteins, including glycolytic enzymes, haemoglobin and cytoskeletal elements.
* Key recommended reading is highlighted with an asterisk
* Alper SL. (2009) Molecular physiology and genetics of Na+-independent SLC4 anion exchangers. J. Exp. Biol., 212 (Pt 11): 1672-83. [PMID:19448077]
* Boron WF, Chen L, Parker MD. (2009) Modular structure of sodium-coupled bicarbonate transporters. J. Exp. Biol., 212 (Pt 11): 1697-706. [PMID:19448079]
* Christensen HL, Nguyen AT, Pedersen FD, Damkier HH. (2013) Na(+) dependent acid-base transporters in the choroid plexus; insights from slc4 and slc9 gene deletion studies. Front Physiol, 4: 304. [PMID:24155723]
* Kurtz I. (2014) NBCe1 as a model carrier for understanding the structure-function properties of Na⁺ -coupled SLC4 transporters in health and disease. Pflugers Arch., 466 (8): 1501-16. [PMID:24515290]
* Liu Y, Wang DK, Chen LM. (2012) The physiology of bicarbonate transporters in mammalian reproduction. Biol. Reprod., 86 (4): 99. [PMID:22262691]
* Majumdar D, Bevensee MO. (2010) Na-coupled bicarbonate transporters of the solute carrier 4 family in the nervous system: function, localization, and relevance to neurologic function. Neuroscience, 171 (4): 951-72. [PMID:20884330]
* Parker MD, Boron WF. (2013) The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters. Physiol. Rev., 93 (2): 803-959. [PMID:23589833]
* Romero MF, Chen AP, Parker MD, Boron WF. (2013) The SLC4 family of bicarbonate (HCO₃⁻) transporters. Mol. Aspects Med., 34 (2-3): 159-82. [PMID:23506864]
Romero MF, Fulton CM, Boron WF. (2004) The SLC4 family of HCO 3 - transporters. Pflugers Arch., 447 (5): 495-509. [PMID:14722772]
* Ruffin VA, Salameh AI, Boron WF, Parker MD. (2014) Intracellular pH regulation by acid-base transporters in mammalian neurons. Front Physiol, 5: 43. [PMID:24592239]
* Thornell IM, Bevensee MO. (2015) Regulators of Slc4 bicarbonate transporter activity. Front Physiol, 6: 166. [PMID:26124722]
Database page citation:
SLC4 family of bicarbonate transporters. Accessed on 23/03/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=142.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Transporters. Br J Pharmacol. 172: 6110-6202.