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Along with the SLC4 family, the SLC26 family acts to allow movement of monovalent and divalent anions across cell membranes. The predicted topology is of 10-14 TM domains with intracellular C- and N-termini, probably existing as dimers. Within the family, subgroups may be identified on the basis of functional differences, which appear to function as anion exchangers and anion channels (SLC26A7 and SLC26A9).
* Key recommended reading is highlighted with an asterisk
* Alper SL, Sharma AK. (2013) The SLC26 gene family of anion transporters and channels. Mol. Aspects Med., 34 (2-3): 494-515. [PMID:23506885]
* Dorwart MR, Shcheynikov N, Yang D, Muallem S. (2008) The solute carrier 26 family of proteins in epithelial ion transport. Physiology (Bethesda), 23: 104-14. [PMID:18400693]
* Kato A, Romero MF. (2011) Regulation of electroneutral NaCl absorption by the small intestine. Annu. Rev. Physiol., 73: 261-81. [PMID:21054167]
* Mount DB, Romero MF. (2004) The SLC26 gene family of multifunctional anion exchangers. Pflugers Arch., 447 (5): 710-21. [PMID:12759755]
* Nofziger C, Dossena S, Suzuki S, Izuhara K, Paulmichl M. (2011) Pendrin function in airway epithelia. Cell. Physiol. Biochem., 28 (3): 571-8. [PMID:22116372]
* Ohana E, Yang D, Shcheynikov N, Muallem S. (2009) Diverse transport modes by the solute carrier 26 family of anion transporters. J. Physiol. (Lond.), 587 (Pt 10): 2179-85. [PMID:19015189]
* Soleimani M. (2013) SLC26 Cl(-)/HCO3(-) exchangers in the kidney: roles in health and disease. Kidney Int., [Epub ahead of print]. [PMID:23636174]
Database page citation:
SLC26 family of anion exchangers. Accessed on 23/03/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=148.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Transporters. Br J Pharmacol. 172: 6110-6202.