SLC10 family of sodium-bile acid co-transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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The SLC10 family transport bile acids, sulphated solutes, and other xenobiotics in a sodium-dependent manner. The founding members, SLC10A1 (NTCP) and SLC10A2 (ASBT) function, along with members of the ABC transporter family (MDR1/ABCB1, BSEP/ABCB11 and MRP2/ABCC2) and the organic solute transporter obligate heterodimer OSTα:OSTβ (SLC51), to maintain the enterohepatic circulation of bile acids [5,14]. SLC10A6 (SOAT) functions as a sodium-dependent transporter of sulphated solutes including sulfphated steroids and bile acids [8,10]. Transport function has not yet been demonstrated for the 4 remaining members of the SLC10 family, SLC10A3 (P3), SLC10A4 (P4), SLC10A5 (P5), and SLC10A7 (P7), and the identity of their endogenous substrates remain unknown [7,10-11,17]. Members of the SLC10 family are predicted to have seven transmembrane domains with an extracellular N-terminus and cytoplasmic C-terminus [1,12].

Transporters

NTCP (Sodium/bile acid and sulphated solute cotransporter 1 / SLC10A1) C Show summary »

ASBT (Sodium/bile acid and sulphated solute cotransporter 2 / SLC10A2) C Show summary »

P3 (Sodium/bile acid and sulphated solute cotransporter 3 / SLC10A3) Show summary »

P4 (Sodium/bile acid and sulphated solute cotransporter 4 / SLC10A4) Show summary »

P5 (Sodium/bile acid and sulphated solute cotransporter 5 / SLC10A5) Show summary »

SOAT (Sodium/bile acid and sulphated solute cotransporter 6 / SLC10A6) C Show summary »

P7 (Sodium/bile acid and sulphated solute cotransporter 7 / SLC10A7) Show summary »

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How to cite this family page

Database page citation:

SLC10 family of sodium-bile acid co-transporters. Accessed on 23/09/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=182.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Transporters. Br J Pharmacol. 172: 6110-6202.