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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Within the SLC13 family, two groups of transporters may be differentiated on the basis of the substrates transported: NaS1 and NaS2 convey sulphate, while NaC1-3 transport carboxylates. NaS1 and NaS2 transporters are made up of 13 TM domains, with an intracellular N terminus and are electrogenic with physiological roles in the intestine, kidney and placenta. NaC1, NaC2 and NaC3 are made up of 11 TM domains with an intracellular N terminus and are electrogenic, with physiological roles in the kidney and liver.
* Key recommended reading is highlighted with an asterisk
Lee A, Dawson PA, Markovich D. (2005) NaSi-1 and Sat-1: structure, function and transcriptional regulation of two genes encoding renal proximal tubular sulfate transporters. Int. J. Biochem. Cell Biol., 37 (7): 1350-6. [PMID:15833267]
Markovich D. (2011) Physiological roles of renal anion transporters NaS1 and Sat1. Am. J. Physiol. Renal Physiol., 300 (6): F1267-70. [PMID:21490138]
* Markovich D. (2014) Na+-sulfate cotransporter SLC13A1. Pflugers Arch., 466 (1): 131-7. [PMID:24193406]
Markovich D, Aronson PS. (2007) Specificity and regulation of renal sulfate transporters. Annu. Rev. Physiol., 69: 361-75. [PMID:17002596]
Markovich D, Murer H. (2004) The SLC13 gene family of sodium sulphate/carboxylate cotransporters. Pflugers Arch., 447 (5): 594-602. [PMID:12915942]
* Pajor AM. (2014) Sodium-coupled dicarboxylate and citrate transporters from the SLC13 family. Pflugers Arch., 466 (1): 119-30. [PMID:24114175]
Database page citation:
SLC13 family of sodium-dependent sulphate/carboxylate transporters. Accessed on 30/04/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=185.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Transporters. Br J Pharmacol. 172: 6110-6202.