SLC13 family of sodium-dependent sulphate/carboxylate transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

GtoImmuPdb view: OFF   

Overview

« Hide

Within the SLC13 family, two groups of transporters may be differentiated on the basis of the substrates transported: NaS1 and NaS2 convey sulphate, while NaC1-3 transport carboxylates. NaS1 and NaS2 transporters are made up of 13 TM domains, with an intracellular N terminus and are electrogenic with physiological roles in the intestine, kidney and placenta. NaC1, NaC2 and NaC3 are made up of 11 TM domains with an intracellular N terminus and are electrogenic, with physiological roles in the kidney and liver.

Transporters

NaS1 (Na+/sulfate cotransporter / SLC13A1) C Show summary »

NaC1 (Na+/dicarboxylate cotransporter 1 / SLC13A2) C Show summary »

NaC3 (Na+/dicarboxylate cotransporter 3 / SLC13A3) C Show summary »

NaS2 (Na+/sulfate cotransporter / SLC13A4) C Show summary »

NaC2 (Na+/citrate cotransporter / SLC13A5) C Show summary »

Further reading

Show »

How to cite this family page

Database page citation:

SLC13 family of sodium-dependent sulphate/carboxylate transporters. Accessed on 25/02/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=185.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Transporters. Br J Pharmacol. 174 Suppl 1: S360-S446.