SLC23 family of ascorbic acid transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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Predicted to be 12 TM segment proteins, members of this family transport the reduced form of ascorbic acid (while the oxidized form may be handled by members of the SLC2 family (GLUT1/SLC2A1, GLUT3/SLC2A3 and GLUT4/SLC2A4). Phloretin is considered a non-selective inhibitor of these transporters, with an affinity in the micromolar range.

Transporters

SVCT1 (Sodium-dependent vitamin C transporter 1 / SLC23A1) C Show summary »

SVCT2 (Sodium-dependent vitamin C transporter 2 / SLC23A2) C Show summary »

SVCT3 (Sodium-dependent vitamin C transporter 3 / SLC23A3) C Show summary »

SNBT1 (Sodium-dependent nucleobase transporter / SLC23A4) C Show summary »

Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

James May. SLC23 family of ascorbic acid transporters. Accessed on 25/05/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=201.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Transporters. Br J Pharmacol. 172: 6110-6202.