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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
The sodium/potassium/calcium exchange family of transporters utilize the extracellular sodium gradient to drive calcium and potassium co-transport out of the cell. As is the case for NCX transporters (SLC8A family), NKCX transporters are thought to be bidirectional, with the possibility of calcium influx following depolarization of the plasma membrane. Topological modeling suggests the presence of 10 TM domains, with a large intracellular loop between the fifth and sixth TM regions.
* Key recommended reading is highlighted with an asterisk
* Altimimi HF, Schnetkamp PP. (2007) Na+/Ca2+-K+ exchangers (NCKX): functional properties and physiological roles. Channels (Austin), 1 (2): 62-9. [PMID:18690016]
Schnetkamp PP. (2004) The SLC24 Na+/Ca2+-K+ exchanger family: vision and beyond. Pflugers Arch., 447 (5): 683-8. [PMID:14770312]
* Schnetkamp PP. (2013) The SLC24 gene family of Na⁺/Ca²⁺-K⁺ exchangers: from sight and smell to memory consolidation and skin pigmentation. Mol. Aspects Med., 34 (2-3): 455-64. [PMID:23506883]
* Schnetkamp PP, Jalloul AH, Liu G, Szerencsei RT. (2014) The SLC24 family of K⁺-dependent Na⁺-Ca²⁺ exchangers: structure-function relationships. Curr Top Membr, 73: 263-87. [PMID:24745986]
* Sekler I. (2015) Standing of giants shoulders the story of the mitochondrial Na(+)Ca(2+) exchanger. Biochem. Biophys. Res. Commun., 460 (1): 50-2. [PMID:25998733]
Database page citation:
SLC24 family of sodium/potassium/calcium exchangers. Accessed on 30/04/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=202.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Transporters. Br J Pharmacol. 172: 6110-6202.