SLC27 family of fatty acid transporters

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Fatty acid transporter proteins (FATPs) are a family (SLC27) of six transporters (FATP1-6). They have at least one, and possibly six [4,11], transmembrane segments, and are predicted on the basis of structural similarities to form dimers. SLC27 members have several structural domains: integral membrane associated domain, peripheral membrane associated domain, FATP signature, intracellular AMP binding motif, dimerization domain, lipocalin motif, and an ER localization domain (identified in FATP4 only) [2,8-9]. These transporters are unusual in that they appear to express intrinsic very long-chain acyl-CoA synthetase (EC 6.2.1.- , EC 6.2.1.7) enzyme activity. Within the cell, these transporters may associate with plasma and peroxisomal membranes. FATP1-4 and -6 transport long- and very long-chain fatty acids, while FATP5 transports long-chain fatty acids as well as bile acids [7,11].

Transporters

FATP1 (Fatty acid transport protein 1 / SLC27A1) Show summary » More detailed page

FATP2 (Fatty acid transport protein 2 / SLC27A2) Show summary »

FATP3 (Fatty acid transport protein 3 / SLC27A3) Show summary »

FATP4 (Fatty acid transport protein 4 / SLC27A4) Show summary »

FATP5 (Fatty acid transport protein 5 / SLC27A5) Show summary »

FATP6 (Fatty acid transport protein 6 / SLC27A6) Show summary »

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How to cite this family page

Database page citation:

SLC27 family of fatty acid transporters. Accessed on 23/03/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=214.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Transporters. Br J Pharmacol. 172: 6110-6202.