SLC39 family of metal ion transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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Along with the SLC30 family, SLC39 family members regulate zinc movement in cells. SLC39 metal ion transporters accumulate zinc into the cytosol. Membrane topology modelling suggests the presence of eight TM regions with both termini extracellular or in the lumen of intracellular organelles. The mechanism for zinc transport for many members is unknown but appears to involve co-transport of bicarbonate ions [2-3].

Transporters

ZIP1 (Zinc transporter 1 / SLC39A1) Show summary »

ZIP2 (Zinc transporter 2 / SLC39A2) Show summary »

ZIP3 (Zinc transporter 3 / SLC39A3) Show summary »

ZIP4 (Zinc transporter 4 / SLC39A4) Show summary »

ZIP5 (Zinc transporter 5 / SLC39A5) Show summary »

ZIP6 (Zinc transporter 6 / SLC39A6) Show summary »

ZIP7 (Zinc transporter 7 / SLC39A7) Show summary »

ZIP8 (Zinc transporter 8 / SLC39A8) C Show summary »

ZIP9 (Zinc transporter 9 / SLC39A9) Show summary »

ZIP10 (Zinc transporter 10 / SLC39A10) Show summary »

ZIP11 (Zinc transporter 11 / SLC39A11) Show summary »

ZIP12 (Zinc transporter 12 / SLC39A12) Show summary »

ZIP13 (Zinc transporter 13 / SLC39A13) Show summary »

ZIP14 (Zinc transporter 14 / SLC39A14) C Show summary »

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References

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How to cite this family page

Database page citation:

SLC39 family of metal ion transporters. Accessed on 22/06/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=228.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Transporters. Br J Pharmacol. 172: 6110-6202.