SLC44 choline transporter-like family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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Members of the choline transporter-like family are encoded by five genes (CTL1-CTL5) with further diversity occurring through alternative splicing of CTL1, 4 and 5 [9]. CTL family members are putative 10TM domain proteins with extracellular termini that mediate Na+-independent transport of choline with an affinity that is intermediate to that of the high affinity choline transporter CHT1 (SLC5A7) and the low affinity organic-cation transporters [OCT1 (SLC22A1) and OCT2 (SLC22A2)] [6]. CLT1 is expressed almost ubiquitously in human tissues [11] and mediates choline transport across the plasma and mitochondrial membranes [5]. Transport of choline by CTL2, which in rodents is expressed as two isoforms (CTL2P1 and CLTP2; [3]) in lung, colon, inner ear and spleen and to a lesser extent in brain, tongue, liver, and kidney, has only recently been demonstrated [3,8]. CTL3-5 remain to be characterized functionally.

Transporters

CTL1 (Choline transporter-like 1 / SLC44A1) C Show summary »

CTL2 (Choline transporter-like 2 / SLC44A2) Show summary »

CTL3 (Choline transporter-like 3 / SLC44A3) Show summary »

CTL4 (Choline transporter-like 4 / SLC44A4) Show summary »

CTL5 (Choline transporter-like 5 / SLC44A5) Show summary »

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How to cite this family page

Database page citation:

SLC44 choline transporter-like family. Accessed on 22/06/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=233.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Transporters. Br J Pharmacol. 172: 6110-6202.