2.1.1.- Protein arginine N-methyltransferases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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Protein arginine N-methyltransferases (PRMT, EC 2.1.1.-) encompass histone arginine N-methyltransferases (PRMT4, PRMT7, EC 2.1.1.125) and myelin basic protein N-methyltransferases (PRMT7, EC 2.1.1.126). They are dimeric or tetrameric enzymes which use S-adenosyl methionine as a methyl donor, generating S-adenosylhomocysteine as a by-product. They generate both mono-methylated and di-methylated products; these may be symmetric (SDMA) or asymmetric (NG,NG-dimethyl-L-arginine) versions, where both guanidine nitrogens are monomethylated or one of the two is dimethylated, respectively.

Enzymes

PRMT1 (protein arginine methyltransferase 1 ) Show summary » More detailed page

PRMT2 (protein arginine methyltransferase 2 ) Show summary »

PRMT3 (protein arginine methyltransferase 3) Show summary » More detailed page

PRMT4 (coactivator associated arginine methyltransferase 1) Show summary » More detailed page

PRMT5 (protein arginine methyltransferase 5 ) Show summary » More detailed page

PRMT6 (protein arginine methyltransferase 6) Show summary » More detailed page

PRMT7 (protein arginine methyltransferase 7 ) Show summary » More detailed page

PRMT8 (protein arginine methyltransferase 8) Show summary »

PRMT9 (F-box protein 11) Show summary »

PRMT10 (protein arginine methyltransferase 9) Show summary »

PRMT11 (F-box protein 10) Show summary »

References

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How to cite this family page

Database page citation:

2.1.1.- Protein arginine N-methyltransferases. Accessed on 24/06/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=254.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Enzymes. Br J Pharmacol. 172: 6024-6109.