Carboxylases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The carboxylases allow the production of new carbon-carbon bonds by introducing HCO3- or CO2 into target molecules. Two groups of carboxylase activities, some of which are bidirectional, can be defined on the basis of the cofactor requirement, making use of biotin (EC 6.4.1.-) or vitamin K hydroquinone (EC 4.1.1.-).

Enzymes

Complexes

PCCA,PCCB (Propionyl-CoA carboxylase ) C Show summary »

Enzymes and Subunits

PC (Pyruvate carboxylase) C Show summary »

ACC1 (Acetyl-CoA carboxylase 1) C Show summary »

ACC2 (Acetyl-CoA carboxylase 2) C Show summary »

PCCA (Propionyl-CoA carboxylase α subunit) Show summary »

PCCB (Propionyl-CoA carboxylase β subunit) Show summary »

GGCX (γ-Glutamyl carboxylase) C Show summary » More detailed page

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References

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How to cite this family page

Database page citation:

Carboxylases. Accessed on 23/05/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=255.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Enzymes. Br J Pharmacol. 172: 6024-6109.