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Adenylyl cyclases (ACs) C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Adenylyl cyclase, E.C., converts ATP to cyclic AMP and pyrophosphate. Mammalian membrane-bound adenylyl cyclases (nomenclature as approved by the NC-IUPHAR Subcommittee on Adenylyl cyclases [8]) are typically made up of two clusters of six TM domains separating two intracellular, overlapping catalytic domains that are the target for the nonselective activators forskolin, NKH477 (except AC9, [20]) and Gαs (the stimulatory G protein α subunit). Adenosine and its derivatives (e.g. 2',5'-dideoxyadenosine), acting through the P-site, appear to be physiological inhibitors of adenylyl cyclase activity [26]. Three families of adenylyl cyclase are distinguishable: calmodulin (CALM2, CALM3, CALM1, P62158)-stimulated (AC1, AC3 and AC8), Ca2+-inhibitable (AC5, AC6 and AC9) and Ca2+-insensitive (AC2, AC4 and AC7) forms.


AC1 (adenylyl cyclase 1) C Show summary »

AC2 (adenylyl cyclase 2) C Show summary »

AC3 (adenylyl cyclase 3) C Show summary »

AC4 (adenylyl cyclase 4) C Show summary »

AC5 (adenylyl cyclase 5) C Show summary »

AC6 (adenylyl cyclase 6) C Show summary »

AC7 (adenylyl cyclase 7) C Show summary »

AC8 (adenylyl cyclase 8) C Show summary »

AC9 (adenylyl cyclase 9) C Show summary »


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Further reading

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Carmen W. Dessauer. Adenylyl cyclases (ACs). Accessed on 10/12/2018. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Enzymes. Br J Pharmacol. 174 Suppl 1: S272-S359.