Guanylyl cyclases (GCs) C

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Nitric oxide (NO)-sensitive (soluble) guanylyl cyclase (GTP diphosphate-lyase (cyclising)), E.C. 4.6.1.2, is a heterodimer comprising a β1 subunit and one of two alpha subunits (α1, α2) giving rise to two functionally indistinguishable isoforms, GC-1 (α1β1) and GC-2 (α2β1) [2-3]. A haem group is associated with the β subunit and is the target for the endogenous ligand NO, and, potentially, carbon monoxide [1]. The enzyme converts guanosine-5'-triphosphate to the intracellular second messenger cyclic guanosine-3',5'-monophosphate (cyclic GMP).

The mammalian genome encodes seven transmembrane guanylyl cyclases, GC-A to GC-G, that are homodimeric receptors activated by a diverse range of endogenous ligands. These enzymes also convert guanosine-5'-triphosphate to the intracellular second messenger cyclic guanosine-3',5'-monophosphate (cyclic GMP).

Subfamilies

References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Adrian Hobbs, Scott Waldman, Annie Beuve, Peter Brouckaert, John C. Burnett, Andreas Friebe, John Garthwaite, Doris Koesling, Michaela Kuhn, Lincoln Potter, Harald Schmidt. Guanylyl cyclases (GCs). Accessed on 22/04/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=258.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Enzymes. Br J Pharmacol. 174 Suppl 1: S272-S359.