Phosphodiesterases, 3',5'-cyclic nucleotide (PDEs) C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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3',5'-Cyclic nucleotide phosphodiesterases (PDEs, 3',5'-cyclic-nucleotide 5'-nucleotidohydrolase), E.C., catalyse the hydrolysis of a 3',5'-cyclic nucleotide (usually cyclic AMP or cyclic GMP). Isobutylmethylxanthine is a nonselective inhibitor with an IC50 value in the millimolar range for all isoforms except PDE 8A, 8B and 9A. A 2',3'-cyclic nucleotide 3'-phosphodiesterase (E.C. CNPase) activity is associated with myelin formation in the development of the CNS.


PDE1A (phosphodiesterase 1A) C Show summary »

PDE1B (phosphodiesterase 1B) C Show summary »

PDE1C (phosphodiesterase 1C) C Show summary »

PDE2A (phosphodiesterase 2A) C Show summary »

PDE3A (phosphodiesterase 3A) C Show summary » More detailed page

PDE3B (phosphodiesterase 3B) C Show summary »

PDE4A (phosphodiesterase 4A) C Show summary »

PDE4B (phosphodiesterase 4B) C Show summary » More detailed page

PDE4C (phosphodiesterase 4C) C Show summary »

PDE4D (phosphodiesterase 4D) C Show summary »

PDE5A (phosphodiesterase 5A) C Show summary » More detailed page

PDE6A (phosphodiesterase 6A) C Show summary »

PDE6B (phosphodiesterase 6B) C Show summary » More detailed page

PDE6C (phosphodiesterase 6C) C Show summary »

PDE6D (phosphodiesterase 6D) C Show summary »

PDE6G (phosphodiesterase 6G) C Show summary »

PDE6H (phosphodiesterase 6H) C Show summary »

PDE7A (phosphodiesterase 7A) C Show summary »

PDE7B (phosphodiesterase 7B) C Show summary » More detailed page

PDE8A (phosphodiesterase 8A) C Show summary »

PDE8B (phosphodiesterase 8B) C Show summary »

PDE9A (phosphodiesterase 9A) C Show summary »

PDE10A (phosphodiesterase 10A) C Show summary » More detailed page

PDE11A (phosphodiesterase 11A) C Show summary »


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How to cite this family page

Database page citation:

Phosphodiesterases, 3',5'-cyclic nucleotide (PDEs). Accessed on 24/11/2017. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Enzymes. Br J Pharmacol. 172: 6024-6109.