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- CYP4 family
CYP4 family C
Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Enzymes
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CYP4A11 C Show summary »« Hide summary
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CYP4A22 Show summary »« Hide summary
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CYP4B1 Show summary »« Hide summary
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CYP4F2 C Show summary »« Hide summary
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CYP4F3 C Show summary »« Hide summary
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CYP4F8 C Show summary »« Hide summary
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CYP4F11 Show summary »« Hide summary
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CYP4F12 C Show summary »« Hide summary
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CYP4F22 C Show summary »« Hide summary
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CYP4V2 C Show summary »« Hide summary
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CYP4X1 C Show summary »« Hide summary
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CYP4Z1 C Show summary »« Hide summary
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References
1. Bylund J, Hidestrand M, Ingelman-Sundberg M, Oliw EH. (2000) Identification of CYP4F8 in human seminal vesicles as a prominent 19-hydroxylase of prostaglandin endoperoxides. J. Biol. Chem., 275 (29): 21844-9. [PMID:10791960]
2. Fer M, Corcos L, Dréano Y, Plée-Gautier E, Salaün JP, Berthou F, Amet Y. (2008) Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism. J. Lipid Res., 49 (11): 2379-89. [PMID:18577768]
3. Harmon SD, Fang X, Kaduce TL, Hu S, Raj Gopal V, Falck JR, Spector AA. (2006) Oxygenation of omega-3 fatty acids by human cytochrome P450 4F3B: effect on 20-hydroxyeicosatetraenoic acid production. Prostaglandins Leukot. Essent. Fatty Acids, 75 (3): 169-77. [PMID:16820285]
4. Mizukami Y, Sumimoto H, Isobe R, Minakami S. (1993) Omega-hydroxylation of lipoxin B4 by human neutrophil microsomes: identification of omega-hydroxy metabolite of lipoxin B4 and catalysis by leukotriene B4 omega-hydroxylase (cytochrome P-450LTB omega). Biochim. Biophys. Acta, 1168 (1): 87-93. [PMID:8389204]
5. Nakano M, Kelly EJ, Rettie AE. (2009) Expression and characterization of CYP4V2 as a fatty acid omega-hydroxylase. Drug Metab. Dispos., 37 (11): 2119-22. [PMID:19661213]
6. Nilsson T, Ivanov IV, Oliw EH. (2010) LC-MS/MS analysis of epoxyalcohols and epoxides of arachidonic acid and their oxygenation by recombinant CYP4F8 and CYP4F22. Arch. Biochem. Biophys., 494 (1): 64-71. [PMID:19919823]
7. Shak S, Reich NO, Goldstein IM, Ortiz de Montellano PR. (1985) Leukotriene B4 omega-hydroxylase in human polymorphonuclear leukocytes. Suicidal inactivation by acetylenic fatty acids. J. Biol. Chem., 260 (24): 13023-8. [PMID:2997155]
8. Sontag TJ, Parker RS. (2002) Cytochrome P450 omega-hydroxylase pathway of tocopherol catabolism. Novel mechanism of regulation of vitamin E status. J. Biol. Chem., 277 (28): 25290-6. [PMID:11997390]
9. Stark K, Dostalek M, Guengerich FP. (2008) Expression and purification of orphan cytochrome P450 4X1 and oxidation of anandamide. FEBS J., 275 (14): 3706-17. [PMID:18549450]
How to cite this family page
Database page citation:
CYP4 family. Accessed on 23/09/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=264.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Enzymes. Br J Pharmacol. 172: 6024-6109.
Converts lauric acid to 12-hydroxylauric acid.