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- CYP4 family
CYP4 family C
Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Enzymes
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CYP4A11 C Show summary »« Hide summary
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CYP4A22 Show summary »« Hide summary
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CYP4B1 Show summary »« Hide summary
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CYP4F2 C Show summary »« Hide summary
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CYP4F3 C Show summary »« Hide summary
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CYP4F8 C Show summary »« Hide summary
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CYP4F11 Show summary »« Hide summary
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CYP4F12 C Show summary »« Hide summary
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CYP4F22 C Show summary »« Hide summary
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CYP4V2 C Show summary »« Hide summary
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CYP4X1 C Show summary »« Hide summary
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CYP4Z1 C Show summary »« Hide summary
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References
1. Bylund J, Hidestrand M, Ingelman-Sundberg M, Oliw EH. (2000) Identification of CYP4F8 in human seminal vesicles as a prominent 19-hydroxylase of prostaglandin endoperoxides. J. Biol. Chem., 275 (29): 21844-9. [PMID:10791960]
2. Fer M, Corcos L, Dréano Y, Plée-Gautier E, Salaün JP, Berthou F, Amet Y. (2008) Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism. J. Lipid Res., 49 (11): 2379-89. [PMID:18577768]
3. Harmon SD, Fang X, Kaduce TL, Hu S, Raj Gopal V, Falck JR, Spector AA. (2006) Oxygenation of omega-3 fatty acids by human cytochrome P450 4F3B: effect on 20-hydroxyeicosatetraenoic acid production. Prostaglandins Leukot. Essent. Fatty Acids, 75 (3): 169-77. [PMID:16820285]
4. Mizukami Y, Sumimoto H, Isobe R, Minakami S. (1993) Omega-hydroxylation of lipoxin B4 by human neutrophil microsomes: identification of omega-hydroxy metabolite of lipoxin B4 and catalysis by leukotriene B4 omega-hydroxylase (cytochrome P-450LTB omega). Biochim. Biophys. Acta, 1168 (1): 87-93. [PMID:8389204]
5. Nakano M, Kelly EJ, Rettie AE. (2009) Expression and characterization of CYP4V2 as a fatty acid omega-hydroxylase. Drug Metab. Dispos., 37 (11): 2119-22. [PMID:19661213]
6. Nilsson T, Ivanov IV, Oliw EH. (2010) LC-MS/MS analysis of epoxyalcohols and epoxides of arachidonic acid and their oxygenation by recombinant CYP4F8 and CYP4F22. Arch. Biochem. Biophys., 494 (1): 64-71. [PMID:19919823]
7. Shak S, Reich NO, Goldstein IM, Ortiz de Montellano PR. (1985) Leukotriene B4 omega-hydroxylase in human polymorphonuclear leukocytes. Suicidal inactivation by acetylenic fatty acids. J. Biol. Chem., 260 (24): 13023-8. [PMID:2997155]
8. Sontag TJ, Parker RS. (2002) Cytochrome P450 omega-hydroxylase pathway of tocopherol catabolism. Novel mechanism of regulation of vitamin E status. J. Biol. Chem., 277 (28): 25290-6. [PMID:11997390]
9. Stark K, Dostalek M, Guengerich FP. (2008) Expression and purification of orphan cytochrome P450 4X1 and oxidation of anandamide. FEBS J., 275 (14): 3706-17. [PMID:18549450]
How to cite this family page
Database page citation:
CYP4 family. Accessed on 20/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=264.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Enzymes. Br J Pharmacol. 174 Suppl 1: S272-S359.
Converts lauric acid to 12-hydroxylauric acid.