Inositol monophosphatase C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Inositol monophosphatase (E.C. 3.1.3.25, IMPase, myo-inositol-1(or 4)-phosphate phosphohydrolase) is a magnesium-dependent homodimer which hydrolyses myo-inositol monophosphate to generate myo-inositol and phosphate. Glycerol may be a physiological phosphate acceptor. Li+ is a nonselective un-competitive inhibitor more potent at IMPase 1 (pKi ca. 3.5, [3]; pIC50 3.2, [4]) than IMPase 2 (pIC50 1.8-2.1, [4]). IMPase activity may be inhibited competitively by L690330 (pKi 5.5, [3]), although the enzyme selectivity is not yet established.

Enzymes

IMPase 1 C Show summary » More detailed page

IMPase 2 C Show summary »

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How to cite this family page

Database page citation:

Inositol monophosphatase. Accessed on 24/03/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=282.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Enzymes. Br J Pharmacol. 172: 6024-6109.