Glucagon receptor family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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The glucagon family of receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on the Glucagon receptor family [19]) are activated by the endogenous peptide (27-44 aa) hormones glucagon (GCG, P01275), glucagon-like peptide 1 (GCG, P01275), glucagon-like peptide 2 (GCG, P01275), glucose-dependent insulinotropic polypeptide (also known as gastric inhibitory polypeptide (GIP, P09681)), GHRH (GHRH, P01286) and secretin (SCT, P09683). One common precursor (GCG) generates glucagon (GCG, P01275), glucagon-like peptide 1 (GCG, P01275) and glucagon-like peptide 2 (GCG, P01275) peptides [13]. For a recent review on review the current understanding of the structures of GLP-1 and GLP-1R, the molecular basis of their interaction, and the signaling events associated with it, see de Graaf et al., 2016 [11].

Receptors

GHRH receptor C Show summary » More detailed page

GIP receptor C Show summary » More detailed page

GLP-1 receptor C Show summary » More detailed page

GLP-2 receptor C Show summary » More detailed page

glucagon receptor C Show summary » More detailed page

secretin receptor C Show summary » More detailed page

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Laurence J. Miller, Daniel J. Drucker, Dominique Bataille, Susan Chan, Philippe Delagrange, Burkhard Göke, Kelly E. Mayo, Bernard Thorens, Rebecca Hills. Glucagon receptor family. Accessed on 13/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=29.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: G protein-coupled receptors. Br J Pharmacol. 174 Suppl 1: S17-S129.