Pattern recognition receptors C

Overview

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Pattern Recognition Receptors (PRRs, [2]) (nomenclature as agreed by NC-IUPHAR sub-committee on Pattern Recognition Receptors, [1]) participate in the innate immune response to microbial agents, the stimulation of which leads to activation of intracellular enzymes and regulation of gene transcription. PRRs express multiple leucine-rich regions to bind a range of microbially-derived ligands, termed PAMPs or pathogen-associated molecular patterns, which includes peptides, carbohydrates, peptidoglycans, lipoproteins, lipopolysaccharides, and nucleic acids. PRRs include both cell-surface and intracellular proteins. PRRs may be divided into signalling-associated members, identified here, and endocytic members, the function of which appears to be to recognise particular microbial motifs for subsequent cell attachment, internalisation and destruction. Some are involved in inflammasome formation, and modulation IL-1β cleavage and secretion, and others in the initiation of the type I interferon response.

PRRs included in the Guide To PHARMACOLOGY are:

Catalytic PRRs (see links below this overview)
Toll-like receptors (TLRs)
Nucleotide-binding oligomerization domain-like receptors (NLRs, also known as NOD-like receptors)
RIG-I-like receptors (RLRs)

Non-catalytic pattern recognition receptors
Absent in melanoma (AIM)-like receptors (ALRs)
C-type lectin-like receptors (CLRs), and
Other pattern recognition receptors.

Subfamilies

Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Clare Bryant, Tom Monie. Pattern recognition receptors. Accessed on 14/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=302.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Catalytic receptors. Br J Pharmacol. 174 Suppl 1: S225-S271.