IL-6 receptor family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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The IL-6 receptor family signal through a ternary receptor complex consisting of the cognate receptor and either the IL-6 signal transducer gp130 (IL6ST, P40189) or the oncostatin M-specific receptor, β subunit (OSMR, Q99650), which then activates the JAK/STAT, Ras/Raf/MAPK and PI 3-kinase/PKB signalling modules. Unusually amongst the cytokine receptors, the CNTF receptor is a glycerophosphatidylinositol-linked protein.

Receptors

Complexes

Interleukin-6 receptor C Show summary » More detailed page

Interleukin-11 receptor C Show summary » More detailed page

Interleukin-27 receptor C Show summary » More detailed page

Interleukin-31 receptor C Show summary » More detailed page

Ciliary neutrophic factor receptor C Show summary »

Leukemia inhibitory factor receptor C Show summary »

Oncostatin-M receptor C Show summary » More detailed page

Receptors and Subunits

IL6R (Interleukin-6 receptor, α subunit / interleukin 6 receptor) C Show summary » More detailed page

IL6ST (Interleukin-6 receptor, β subunit / interleukin 6 signal transducer) C Show summary » More detailed page

Interleukin-11 receptor, α subunit C Show summary » More detailed page

Interleukin 27 receptor, alpha C Show summary » More detailed page

Interleukin-31 receptor, α subunit C Show summary » More detailed page

Ciliary neurotrophic factor receptor α subunit C Show summary »

Leptin receptor C Show summary »

Leukemia inhibitory factor receptor C Show summary »

Oncostatin M-specific receptor, β subunit C Show summary » More detailed page

References

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How to cite this family page

Database page citation:

IL-6 receptor family. Accessed on 15/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=307.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Catalytic receptors. Br J Pharmacol. 174 Suppl 1: S225-S271.