IL-6 receptor family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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The IL-6 receptor family signal through a ternary receptor complex consisting of the cognate receptor and either the IL-6 signal transducer gp130 (IL6ST, P40189) or the oncostatin M-specific receptor, β subunit (OSMR, Q99650), which then activates the JAK/STAT, Ras/Raf/MAPK and PI 3-kinase/PKB signalling modules. Unusually amongst the cytokine receptors, the CNTF receptor is a glycerophosphatidylinositol-linked protein.

Receptors

Complexes

Interleukin-6 receptor C Show summary » More detailed page

Interleukin-11 receptor C Show summary » More detailed page

Interleukin-27 receptor C Show summary » More detailed page

Interleukin-31 receptor C Show summary » More detailed page

Ciliary neutrophic factor receptor C Show summary »

Leukemia inhibitory factor receptor C Show summary »

Oncostatin-M receptor C Show summary » More detailed page

Receptors and Subunits

IL6R (Interleukin-6 receptor, α subunit / interleukin 6 receptor) C Show summary » More detailed page

IL6ST (Interleukin-6 receptor, β subunit / interleukin 6 signal transducer) C Show summary » More detailed page

Interleukin-11 receptor, α subunit C Show summary » More detailed page

Interleukin 27 receptor, alpha C Show summary » More detailed page

Interleukin-31 receptor, α subunit C Show summary » More detailed page

Ciliary neurotrophic factor receptor α subunit C Show summary »

Leptin receptor C Show summary »

Leukemia inhibitory factor receptor C Show summary »

Oncostatin M-specific receptor, β subunit C Show summary » More detailed page

References

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How to cite this family page

Database page citation:

IL-6 receptor family. Accessed on 21/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=307.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Catalytic receptors. Br J Pharmacol. 172: 5979-6023.