Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family C

Formerly known as: Leukocyte tyrosine kinase (LTK) receptor family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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The LTK family appear to lack endogenous ligands. LTK is subject to tissue-specific splice variation, which appears to generate products in distinct subcellular locations. ALK fusions created by gene translocations and rearrangements are associated with many types of cancer, including large cell lymphomas, inflammatory myofibrilastic tumours and non-small cell lung cancer [6].

Receptors

LTK (leukocyte receptor tyrosine kinase) C Show summary » More detailed page

ALK (ALK receptor tyrosine kinase) C Show summary » More detailed page

References

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How to cite this family page

Database page citation:

Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family. Accessed on 24/11/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=329.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Catalytic receptors. Br J Pharmacol. 172: 5979-6023.