Receptor tyrosine phosphatase (RTP) family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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Receptor tyrosine phosphatases (RTP) are cell-surface proteins with a single TM region and intracellular phosphotyrosine phosphatase activity. Many family members exhibit constitutive activity in heterologous expression, dephosphorylating intracellular targets such as Src tyrosine kinase (SRC) to activate signalling cascades. Family members bind components of the extracellular matrix or cell-surface proteins indicating a role in intercellular communication.

Receptors

RTP Type A C Show summary »

RTP Type B C Show summary » More detailed page

RTP Type C C Show summary » More detailed page

RTP Type D C Show summary »

RTP Type E C Show summary »

RTP Type F C Show summary » More detailed page

RTP Type G C Show summary »

RTP Type H C Show summary »

RTP Type J C Show summary »

RTP Type K C Show summary »

RTP Type M C Show summary »

RTP Type N C Show summary »

RTP Type N2 C Show summary »

RTP Type O C Show summary »

RTP Type Q C Show summary »

RTP Type R C Show summary »

RTP Type S C Show summary »

RTP Type T C Show summary »

RTP Type U C Show summary »

RTP Type Z1 C Show summary »

Further reading

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References

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How to cite this family page

Database page citation:

Receptor tyrosine phosphatase (RTP) family. Accessed on 24/08/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=333.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Catalytic receptors. Br J Pharmacol. 172: 5979-6023.