Tumour necrosis factor (TNF) receptor family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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Dyregulated TNFR signalling is associated with many inflammatory disorders, including some forms of arthritis and inflammatory bowel disease, and targeting TNF has been an effective therapeutic strategy in these diseases and for cancer immunotherapy [1-2,5].

Receptors

TNFR1 (tumor necrosis factor receptor 1 / TNFRSF1A) C Show summary » More detailed page

TNFR2 (tumor necrosis factor receptor 2 / TNFRSF1B) C Show summary » More detailed page

lymphotoxin β receptor / TNFRSF3 C Show summary » More detailed page

OX40 / TNFRSF4 C Show summary » More detailed page

CD40 / TNFRSF5 C Show summary » More detailed page

Fas / TNFRSF6 C Show summary » More detailed page

decoy receptor 3 / TNFRSF6B C Show summary » More detailed page

CD27 / TNFRSF7 C Show summary » More detailed page

CD30 / TNFRSF8 C Show summary » More detailed page

4-1BB / TNFRSF9 C Show summary » More detailed page

DR4 (death receptor 4 / TNFRSF10A) C Show summary »

DR5 (death receptor 5 / TNFRSF10B) C Show summary »

decoy receptor 1 / TNFRSF10C C Show summary »

decoy receptor 2 / TNFRSF10D C Show summary »

RANK (receptor activator of NF-kappa B / TNFRSF11A) C Show summary » More detailed page

OPG (osteoprotegerin / TNFRSF11B) C Show summary » More detailed page

DR3 (death receptor 3 / TNFRSF25) C Show summary » More detailed page

TWEAK receptor / TNFRSF12A C Show summary » More detailed page

TACI / TNFRSF13B C Show summary » More detailed page

BAFF-R (BAFF receptor / TNFRSF13C) C Show summary » More detailed page

HVEM (herpes virus entry mediator / TNFRSF14) C Show summary » More detailed page

nerve growth factor receptor / TNFRSF16 C Show summary »

BCMA (B cell maturation antigen / TNFRSF17) C Show summary » More detailed page

GITR (glucocorticoid-induced TNF receptor / TNFRSF18) C Show summary » More detailed page

TAJ (toxicity and JNK inducer / TNFRSF19) C Show summary » More detailed page

RELT / TNFRSF19L C Show summary » More detailed page

DR6 (death receptor 6 / TNFRSF21) C Show summary » More detailed page

TNFRSF22 C Show summary »

TNFRSF23 C Show summary »

ectodysplasin A2 isoform receptor / TNFRS27 C Show summary »

ectodysplasin 1, anhidrotic receptor C Show summary »

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Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

David MacEwan. Tumour necrosis factor (TNF) receptor family. Accessed on 23/06/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=334.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Catalytic receptors. Br J Pharmacol. 172: 5979-6023.