SLC49 family of FLVCR-related heme transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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FLVCR1 was initially identified as a cell-surface attachment site for feline leukemia virus subgroup C [9], and later identified as a cell surface accumulation which exports heme from the cytosol [6]. A recent study indicates that an isoform of FLVCR1 is located in the mitochondria, the site of the final steps of heme synthesis, and appears to transport heme into the cytosol [2]. FLVCR-mediated heme transport is essential for erythropoiesis. Flvcr1 gene mutations have been identified as the cause of PCARP (posterior column ataxia with retinitis pigmentosa (PCARP) [7].There are three paralogs of FLVCR1 in the human genome.

FLVCR2, most similar to FLVCR1 [4], has been reported to function as a heme importer [3]. In addition, a congenital syndrome of proliferative vasculopathy and hydranencephaly, also known as Fowler's syndrome, is associated with a loss-of-function mutation in FLVCR2 [5].

The functions of the other two members of the SLC49 family, MFSD7 and DIRC2, are unknown, although DIRC2 has been implicated in hereditary renal carcinomas [1].

Transporters

FLVCR1 (Feline leukemia virus subgroup C cellular receptor family, member 1 / SLC49A1) C Show summary »

FLVCR2 (Feline leukemia virus subgroup C cellular receptor family, member 2 / SLC49A2) C Show summary »

MFSD7 (Major facilitator superfamily domain containing 7 / SLC49A3) Show summary »

DIRC2 (Disrupted in renal carcinoma 2 / SLC49A4) Show summary »

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How to cite this family page

Database page citation:

SLC49 family of FLVCR-related heme transporters. Accessed on 13/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=335.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Transporters. Br J Pharmacol. 174 Suppl 1: S360-S446.