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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
The SLC51 organic solute transporter family of transporters is a pair of heterodimeric proteins which regulate bile salt movements in the bile duct, small intestine and kidney, and elsewhere, as part of the enterohepatic circulation [1,3]. OSTα/OSTβ is also expressed in steroidogenic cells of the brain and adrenal gland, where it may contribute to steroid movement . Bile acid transport is suggested to be facilitative and independent of sodium, potassium, chloride ions or protons [1,3]. OSTα/OSTβ heterodimers have been shown to transport [3H]taurocholic acid, [3H]dehydroepiandrosterone sulphate, [3H]estrone-3-sulphate, [3H]pregnenolone sulphate and [3H]dehydroepiandrosterone sulphate [1,3-4]. OSTα is suggested to be a seven TM protein, while OSTβ is a single TM ‘ancillary’ protein, both of which are thought to have intracellular C-termini . Bimolecular fluorescence complementation studies suggest the possibility of OSTα homo-oligomers, as well as OSTα/OSTβ hetero-oligomers [2,5].
* Key recommended reading is highlighted with an asterisk
* Ballatori N. (2011) Pleiotropic functions of the organic solute transporter Ostα-Ostβ. Dig Dis, 29 (1): 13-7. [PMID:21691099]
* Ballatori N, Christian WV, Wheeler SG, Hammond CL. (2013) The heteromeric organic solute transporter, OSTα-OSTβ/SLC51: a transporter for steroid-derived molecules. Mol. Aspects Med., 34 (2-3): 683-92. [PMID:23506901]
* Dawson PA. (2011) Role of the intestinal bile acid transporters in bile acid and drug disposition. Handb Exp Pharmacol, (201): 169-203. [PMID:21103970]
1. Ballatori N, Christian WV, Lee JY, Dawson PA, Soroka CJ, Boyer JL, Madejczyk MS, Li N. (2005) OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia. Hepatology, 42 (6): 1270-9. [PMID:16317684]
2. Christian WV, Li N, Hinkle PM, Ballatori N. (2012) β-Subunit of the Ostα-Ostβ organic solute transporter is required not only for heterodimerization and trafficking but also for function. J. Biol. Chem., 287 (25): 21233-43. [PMID:22535958]
3. Dawson PA, Hubbert M, Haywood J, Craddock AL, Zerangue N, Christian WV, Ballatori N. (2005) The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter. J. Biol. Chem., 280 (8): 6960-8. [PMID:15563450]
4. Fang F, Christian WV, Gorman SG, Cui M, Huang J, Tieu K, Ballatori N. (2010) Neurosteroid transport by the organic solute transporter OSTα-OSTβ. J. Neurochem., 115 (1): 220-33. [PMID:20649839]
5. Li N, Cui Z, Fang F, Lee JY, Ballatori N. (2007) Heterodimerization, trafficking and membrane topology of the two proteins, Ost alpha and Ost beta, that constitute the organic solute and steroid transporter. Biochem. J., 407 (3): 363-72. [PMID:17650074]
Database page citation:
SLC51 family of steroid-derived molecule transporters. Accessed on 23/03/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=337.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Transporters. Br J Pharmacol. 172: 6110-6202.