Melanocortin receptors C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Melanocortin receptors (provisional nomenclature as recommended by NC-IUPHAR [4]) are activated by members of the melanocortin family (α-MSH (POMC, P01189), β-MSH (POMC, P01189) and γ-MSH (POMC, P01189) forms; δ form is not found in mammals) and adrenocorticotrophin (ACTH (POMC, P01189)). Endogenous antagonists include agouti (ASIP, P42127) and agouti-related protein (AGRP, O00253). ACTH(1-24) was approved by the US FDA as a diagnostic agent for adrenal function test. At least 2 synthetic melanocortin receptor agonists are under clinical development as of 2017.

Receptors

MC1 receptor C Show summary » More detailed page

MC2 receptor C Show summary » More detailed page

MC3 receptor C Show summary » More detailed page

MC4 receptor C Show summary » More detailed page

MC5 receptor C Show summary » More detailed page

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Tung M. Fong, Helgi Schiöth, Ira Gantz, Vanni Caruso, Roger D. Cone, Sadaf Farooqi, Carrie Haskell-Luevano, Victor J. Hruby, Kathleen G. Mountjoy, Jarl E. S. Wikberg, Biao-Xin Chai, Adrian J. L. Clark, Alex N. Eberle, Colin Pouton, Jeffrey B. Tatro. Melanocortin receptors. Accessed on 27/04/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=38.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Davenport AP, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors. Br J Pharmacol. 172: 5744-5869.