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CRK7 subfamily

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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CDK12 and CDK13 are C-terminal domain (CTD) serine kinases that phosphorylate Ser2 in the CTD of RNA polymerase II and which regulate co-transcriptional processing, including splicing and 3'-end RNA processing [1,3-5]. Although CDK12 and CDK13 are closely related structurally, they differ in function. Whilst CDK12 is essential for the expression of genes that are involved in the DNA damage response pathway [2] (generally longer genes with a high number of exons), CDK13 activity affects genes that are required for protein translation.

Enzymes

CDK12 (cyclin dependent kinase 12) Show summary » More detailed page

CDK13 (cyclin dependent kinase 13) Show summary » More detailed page

References

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How to cite this family page

Database page citation:

CRK7 subfamily. Accessed on 12/12/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=490.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Enzymes. Br J Pharmacol. 174 Suppl 1: S272-S359.