P2Y receptors C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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P2Y receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on P2Y Receptors [1-2]) are activated by the endogenous ligands ATP, ADP, uridine triphosphate, uridine diphosphate and UDP-glucose. The relationship of many of the cloned receptors to endogenously expressed receptors is not yet established and so it might be appropriate to use wording such as 'uridine triphosphate-preferring (or ATP-, etc.) P2Y receptor' or 'P2Y1-like', etc., until further, as yet undefined, corroborative criteria can be applied [13,27,39,67,70].

Clinically used drugs acting on these receptors include the dinucleoside polyphosphate diquafosol, agonist of the P2Y2 receptor subtype, approved in Japan for the management of dry eye disease [52], and the P2Y12 receptor antagonists prasugrel, ticagrelor and cangrelor, all approved as antiplatelet drugs [15,63].

Receptors

P2Y1 receptor C Show summary » More detailed page

P2Y2 receptor C Show summary » More detailed page

P2Y4 receptor C Show summary » More detailed page

P2Y6 receptor C Show summary » More detailed page

P2Y11 receptor C Show summary » More detailed page

P2Y12 receptor C Show summary » More detailed page

P2Y13 receptor C Show summary » More detailed page

P2Y14 receptor C Show summary » More detailed page

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Maria-Pia Abbracchio, Kenneth A. Jacobson, Geoffrey Burnstock, Jean-Marie Boeynaems, José L. Boyer, Stefania Ceruti, Marta Fumagalli, Christian Gachet, Robert G. Humphries, Charles Kennedy, Brian F. King, Davide Lecca, Maria Teresa Miras-Portugal, Gary A. Weisman, Kazu Inoue, Vera Ralevic, Rebecca Hills. P2Y receptors. Accessed on 23/07/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=52.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Davenport AP, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors. Br J Pharmacol. 172: 5744-5869.