MST subfamily

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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MST1 (STK3) and MST2 (STK4) are the mammalian homologs of Drosophila Hippo (Hpo), and are core components of the Hippo pathway, which is essentially a kinase cascade whose terminal output regulates the activities of the transcriptional coactivators, Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ), and controls expression of a diverse set of genes that are involved in cell proliferation, survival, and migration. Hippo signalling has traditionally been viewed as a key regulator of organ growth and development, tissue homeostasis and tumour suppression in multiple organisms [3]. More recent studies have identified new roles for the Hippo pathway in immunology [1-2,4].

Enzymes

MST2 (serine/threonine kinase 3) Show summary » More detailed page

MST1 (serine/threonine kinase 4) Show summary » More detailed page

References

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How to cite this family page

Database page citation:

MST subfamily. Accessed on 20/10/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=545.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Enzymes. Br J Pharmacol. 174 Suppl 1: S272-S359.