Prokineticin receptors

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Prokineticin receptors, PKR1 and PKR2 (provisional nomenclature as recommended by NC-IUPHAR [5]) respond to the cysteine-rich 81-86 amino-acid peptides prokineticin-1 (PROK1, Q9HC23) (also known as endocrine gland-derived vascular endothelial growth factor, mambakine) and prokineticin-2 (PROK2, Q9HC23) (protein Bv8 homologue). An orthologue of PROK1 from black mamba (Dendroaspis polylepis) venom, mamba intestinal toxin 1 (MIT1, [16]) is a potent, non-selective agonist at prokineticin receptors [10], while Bv8, an orthologue of PROK2 from amphibians (Bombina sp., [11]), is equipotent at recombinant PKR1 and PKR2 [12], and has high potency in macrophage chemotaxis assays, which are lost in PKR1-null mice.

Receptors

PKR1 Show summary » More detailed page

PKR2 Show summary » More detailed page

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Philippe Rondard, Oualid Sbai, Qun-Yong Zhou, Rebecca Hills. Prokineticin receptors. Accessed on 23/03/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=56.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Davenport AP, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors. Br J Pharmacol. 172: 5744-5869.