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Angiotensin receptors C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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The actions of angiotensin II (AGT, P01019) (Ang II) are mediated by AT1 and AT2 receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Angiotensin receptors [11,19]), which have around 30% sequence similarity. The decapeptide angiotensin I (AGT, P01019), the octapeptide angiotensin II (AGT, P01019) and the heptapeptide angiotensin III (AGT, P01019) are endogenous ligands. Losartan, candesartan, telmisartan, etc. are clinically used AT1 receptor blockers.


AT1 receptor C Show summary » More detailed page

AT2 receptor C Show summary » More detailed page


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Further reading

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Sadashiva Karnik, Kenneth E. Bernstein, Jacqueline Kemp, Satoru Eguchi, Emanuel Escher, László Hunyady, Kalyan Tirupula, Patrick Vanderheyden, Hamiyet Unal, Marc de Gasparo, Khuraijam Dhanachandra Singh, Walter (Wally) Thomas, Wayne Alexander, Kevin J. Catt, Theodore L. Goodfriend, Mastgugu Horiuchi, Ahsan Husain, Tadashi Inagami, Pieter B. M. W. M. Timmermans, Thomas Unger. Angiotensin receptors. Accessed on 10/12/2018. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: G protein-coupled receptors. Br J Pharmacol. 174 Suppl 1: S17-S129.