Receptor Guanylyl Cyclase (RGC) family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The mammalian genome encodes seven transmembrane guanylyl cyclases, GC-A to GC-G, that are homodimeric receptors activated by a diverse range of endogenous ligands. These enzymes also convert guanosine-5'-triphosphate to the intracellular second messenger cyclic guanosine-3',5'-monophosphate (cyclic GMP).

Receptors

GC-A (Guanylyl cyclase-A) Show summary » More detailed page

GC-B (Guanylyl cyclase-B) C Show summary » More detailed page

GC-C (Guanylyl cyclase-C) C Show summary » More detailed page

GC-D (Guanylyl cyclase-D) C Show summary » More detailed page

GC-E (Guanylyl cyclase-E) C Show summary » More detailed page

GC-F (Guanylyl cyclase-F) C Show summary » More detailed page

GC-G (Guanylyl cyclase-G) C Show summary » More detailed page

References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Adrian Hobbs, Scott Waldman, Annie Beuve, Peter Brouckaert, John C. Burnett, Andreas Friebe, John Garthwaite, Doris Koesling, Michaela Kuhn, Lincoln Potter, Harald Schmidt. Receptor Guanylyl Cyclase (RGC) family. Accessed on 27/03/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=662.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Catalytic receptors. Br J Pharmacol. 172: 5979-6023.