T1: Proteasome C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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The T1 macropain beta subunits form the catalytic proteinase core of the 20S proteasome complex [1]. This catalytic core enables the degradation of peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the cleavage site. The β5 subunit is the principal target of the approved drug proteasome inhibitor bortezomib.

Enzymes

proteasome subunit beta 1 Show summary » More detailed page

proteasome subunit beta 2 Show summary » More detailed page

proteasome subunit beta 5 C Show summary » More detailed page

proteasome subunit beta 6 Show summary » More detailed page

proteasome subunit beta 8 Show summary » More detailed page

proteasome subunit beta 9 Show summary » More detailed page

References

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How to cite this family page

Database page citation:

T1: Proteasome. Accessed on 27/05/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=752.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Enzymes. Br J Pharmacol. 172: 6024-6109.