Two P domain potassium channels C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

« Hide More detailed introduction

The 4TM family of K channels mediate many of the background potassium currents observed in native cells. They are open across the physiological voltage-range and are regulated by a wide array of neurotransmitters and biochemical mediators. The pore-forming α-subunit contains two pore loop (P) domains and two subunits assemble to form one ion conduction pathway lined by four P domains. It is important to note that single channels do not have two pores but that each subunit has two P domains in its primary sequence; hence the name two-pore domain, or K2P channels (and not two-pore channels). Some of the K2P subunits can form heterodimers across subfamilies (e.g. K2P3.1 with K2P9.1). The nomenclature of 4TM K channels in the literature is still a mixture of IUPHAR and common names. The suggested division into subfamilies, below, is based on similarities in both structural and functional properties within subfamilies.

Channels and Subunits

K2P1.1 C Show summary » More detailed page

K2P2.1 C Show summary » More detailed page

K2P3.1 C Show summary » More detailed page

K2P4.1 C Show summary » More detailed page

K2P5.1 C Show summary » More detailed page

K2P6.1 C Show summary » More detailed page

K2P7.1 C Show summary » More detailed page

K2P9.1 C Show summary » More detailed page

K2P10.1 C Show summary » More detailed page

K2P12.1 C Show summary » More detailed page

K2P13.1 C Show summary » More detailed page

K2P15.1 C Show summary » More detailed page

K2P16.1 C Show summary » More detailed page

K2P17.1 C Show summary » More detailed page

K2P18.1 C Show summary » More detailed page

Comments

Show »

References

Show »

NC-IUPHAR subcommittee and family contributors

Show »

How to cite this family page

Database page citation:

Leigh D. Plant, Douglas A. Bayliss, Daniel L. Minor, Jr., Gábor Czirják, Péter Enyedi, Florian Lesage, Francisco Sepúlveda, Steve A.N. Goldstein. Two P domain potassium channels. Accessed on 23/04/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=79.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Catterall WA, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Voltage-gated ion channels. Br J Pharmacol. 172: 5904-5941.