Two P domain potassium channels C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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The 4TM family of K channels mediate many of the background potassium currents observed in native cells. They are open across the physiological voltage-range and are regulated by a wide array of neurotransmitters and biochemical mediators. The pore-forming α-subunit contains two pore loop (P) domains and two subunits assemble to form one ion conduction pathway lined by four P domains. It is important to note that single channels do not have two pores but that each subunit has two P domains in its primary sequence; hence the name two-pore domain, or K2P channels (and not two-pore channels). Some of the K2P subunits can form heterodimers across subfamilies (e.g. K2P3.1 with K2P9.1). The nomenclature of 4TM K channels in the literature is still a mixture of IUPHAR and common names. The suggested division into subfamilies, below, is based on similarities in both structural and functional properties within subfamilies.

Channels and Subunits

K2P1.1 C Show summary » More detailed page

K2P2.1 C Show summary » More detailed page

K2P3.1 C Show summary » More detailed page

K2P4.1 C Show summary » More detailed page

K2P5.1 C Show summary » More detailed page

K2P6.1 C Show summary » More detailed page

K2P7.1 C Show summary » More detailed page

K2P9.1 C Show summary » More detailed page

K2P10.1 C Show summary » More detailed page

K2P12.1 C Show summary » More detailed page

K2P13.1 C Show summary » More detailed page

K2P15.1 C Show summary » More detailed page

K2P16.1 C Show summary » More detailed page

K2P17.1 C Show summary » More detailed page

K2P18.1 C Show summary » More detailed page

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Leigh D. Plant, Douglas A. Bayliss, Daniel L. Minor, Jr., Gábor Czirják, Péter Enyedi, Florian Lesage, Francisco Sepúlveda, Steve A.N. Goldstein. Two P domain potassium channels. Accessed on 11/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=79.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Striessnig J, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Voltage-gated ion channels. Br J Pharmacol. 174 Suppl 1: S160-S194.