Hydrolases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

GtoImmuPdb view: OFF   

Overview

« Hide

Listed in this section are hydrolases not accumulated in other parts of the Concise Guide, such as monoacylglycerol lipase and acetylcholinesterase. Pancreatic lipase is the predominant mechanism of fat digestion in the alimentary system; its inhibition is associated with decreased fat absorption. CES1 is present at lower levels in the gut than CES2 (P23141), but predominates in the liver, where it is responsible for the hydrolysis of many aliphatic, aromatic and steroid esters. Hormone-sensitive lipase is also a relatively non-selective esterase associated with steroid ester hydrolysis and triglyceride metabolism, particularly in adipose tissue. Endothelial lipase is secreted from endothelial cells and regulates circulating cholesterol in high density lipoproteins.

Enzymes

DAGLα (Diacylglycerol lipase α) C Show summary » More detailed page

FAAH (Fatty acid amide hydrolase) C Show summary » More detailed page

PLD2 C Show summary » More detailed page

DAGLβ (Diacylglycerol lipase β) C Show summary » More detailed page

MAGL (Monoacylglycerol lipase) C Show summary » More detailed page

sPLA2-2A C Show summary » More detailed page

PLA2-G7 C Show summary » More detailed page

AChE (acetylcholinesterase (Cartwright blood group)) C Show summary » More detailed page

Leukotriene A4 hydrolase Show summary » More detailed page

BChE (butyrylcholinesterase) C Show summary » More detailed page

PNLIP (pancreatic lipase) C Show summary » More detailed page

LIPG (lipase G, endothelial type) C Show summary » More detailed page

CES1 (carboxylesterase 1) C Show summary » More detailed page

LIPE (lipase E, hormone sensitive type) C Show summary » More detailed page

NTPDase-1 (ectonucleoside triphosphate diphosphohydrolase 1 / CD39) C Show summary » More detailed page

NTPDase-2 (ectonucleoside triphosphate diphosphohydrolase 2 / CD39L1) C Show summary » More detailed page

epoxide hydrolase 2 Show summary » More detailed page

Further reading

Show »

References

Show »

NC-IUPHAR subcommittee and family contributors

Show »

How to cite this family page

Database page citation:

Hydrolases. Accessed on 17/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=799.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Enzymes. Br J Pharmacol. 174 Suppl 1: S272-S359.