Voltage-gated potassium channels

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The 6TM family of K channels comprises the voltage-gated KV subfamilies, the EAG subfamily (which includes hERG channels), the Ca2+-activated Slo subfamily (actually with 7TM, termed BK) and the Ca2+-activated SK subfamily. These channels possess a pore-forming α subunit that comprise tetramers of identical subunits (homomeric) or of different subunits (heteromeric). Heteromeric channels can only be formed within subfamilies (e.g. Kv1.1 with Kv1.2; Kv7.2 with Kv7.3). The pharmacology largely reflects the subunit composition of the functional channel.

Channels and Subunits

Kv1.1 Show summary » More detailed page

Kv1.2 Show summary » More detailed page

Kv1.3 Show summary » More detailed page

Kv1.4 Show summary » More detailed page

Kv1.5 Show summary » More detailed page

Kv1.6 Show summary » More detailed page

Kv1.7 Show summary » More detailed page

Kv1.8 Show summary » More detailed page

Kv2.1 Show summary » More detailed page

Kv2.2 Show summary » More detailed page

Kv3.1 Show summary » More detailed page

Kv3.2 Show summary » More detailed page

Kv3.3 Show summary » More detailed page

Kv3.4 Show summary » More detailed page

Kv4.1 Show summary » More detailed page

Kv4.2 Show summary » More detailed page

Kv4.3 Show summary » More detailed page

Kv5.1 Show summary » More detailed page

Kv6.1 Show summary » More detailed page

Kv6.2 Show summary » More detailed page

Kv6.3 Show summary » More detailed page

Kv6.4 Show summary » More detailed page

Kv7.1 Show summary » More detailed page

Kv7.2 Show summary » More detailed page

Kv7.3 Show summary » More detailed page

Kv7.4 Show summary » More detailed page

Kv7.5 Show summary » More detailed page

Kv8.1 Show summary » More detailed page

Kv8.2 Show summary » More detailed page

Kv9.1 Show summary » More detailed page

Kv9.2 Show summary » More detailed page

Kv9.3 Show summary » More detailed page

Kv10.1 Show summary » More detailed page

Kv10.2 Show summary » More detailed page

Kv11.1 Show summary » More detailed page

Kv11.2 Show summary » More detailed page

Kv11.3 Show summary » More detailed page

Kv12.1 Show summary » More detailed page

Kv12.2 Show summary » More detailed page

Kv12.3 Show summary » More detailed page

References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Lily Y. Jan, Bernard Attali, Jeanne Nerbonne, Michael C. Sanguinetti, James S. Trimmer, K. George Chandy, Stephan Grissmer, George A. Gutman, Michel Lazdunski, David Mckinnon, Luis A. Pardo, Gail A. Robertson, Bernardo Rudy, Walter Stühmer, Xiaoliang Wang. Voltage-gated potassium channels. Accessed on 21/02/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=81.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Catterall WA, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Voltage-gated ion channels. Br J Pharmacol. 172: 5904-5941.