CD molecules C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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Cluster of differentiation refers to an attempt to catalogue systematically a series of over 300 cell-surface proteins associated with immunotyping. Many members of the group have identified functions as enzymes (for example, see CD73 ecto-5'-nucleotidase) or receptors (for example, see CD41 integrin, alpha 2b subunit). Many CDs are targeted for therapeutic gain using antibodies for the treatment of proliferative disorders. A full listing of all the Clusters of Differentiation proteins is not possible in the Guide to PHARMACOLOGY; listed herein are selected members of the family targeted for therapeutic gain.

Targets

CD2 C Show summary » More detailed page

CD3e C Show summary » More detailed page

CD6 C Show summary » More detailed page

CD19 Show summary » More detailed page

CD20 (membrane-spanning 4-domains, subfamily A, member 1) C Show summary » More detailed page

SIGLEC-2 (CD22) Show summary » More detailed page

CD28 Show summary » More detailed page

SIGLEC-3 (CD33) C Show summary » More detailed page

CD38 Show summary » More detailed page

CD47 Show summary » More detailed page

CD52 C Show summary » More detailed page

NCAM1 (neural cell adhesion molecule 1 (CD56)) Show summary » More detailed page

CD66e (CEACAM5) Show summary » More detailed page

CD74 Show summary » More detailed page

CD79B Show summary » More detailed page

CD80 C Show summary » More detailed page

LILRA4 (CD85g) Show summary » More detailed page

CD86 C Show summary » More detailed page

semaphorin 4D (CD100) Show summary » More detailed page

endoglin (CD105) Show summary » More detailed page

CTLA-4 (cytotoxic T-lymphocyte-associated protein 4 (CD152)) C Show summary » More detailed page

NKG2A (CD159a) Show summary » More detailed page

SIRPA (CD172a) Show summary » More detailed page

LAG3 (CD223) / CD223 Show summary » More detailed page

B7-H3 (CD276) Show summary » More detailed page

ICOS (CD278) Show summary » More detailed page

PD-1 (programmed cell death 1 (CD279)) C Show summary » More detailed page

CD300a C Show summary » More detailed page

CS1 (CD319) Show summary » More detailed page

TIM3 (CD366) Show summary » More detailed page

References

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How to cite this family page

Database page citation:

CD molecules. Accessed on 18/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=852.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Buneman OP, Catterall WA, Cidlowski JA, Davenport AP, Fabbro D, Fan G, McGrath JC, Spedding M, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Overview. Br J Pharmacol. 172: 5729-5743.